The paper presents the fifth release of the UMIST Database for Astrochemistry (UDfa), known as RArte12, which includes 6173 gas-phase reactions involving 467 species, with 47 new additions. The database has been updated with rate coefficients for all reaction types, including 1171 new anion reactions and updated photorates. New features include state-specific deuterated rate coefficients, deuterium exchange reactions, and surface binding energies for many neutral species. The authors have tested the main reaction network using dark cloud and carbon-rich circumstellar envelope models, demonstrating its applicability to various astrophysical environments. The paper discusses the improvements in the new version, such as the inclusion of anion reactions and updated dissociative recombination rates, and compares the results with observations of TMC-1 and IRC+10216. The models show reasonable agreement with observations, highlighting the importance of accurate rate coefficients, especially at low temperatures. The paper also discusses the impact of anions on the chemistry in circumstellar envelopes, showing how they affect the ionization balance and the abundances of various species.The paper presents the fifth release of the UMIST Database for Astrochemistry (UDfa), known as RArte12, which includes 6173 gas-phase reactions involving 467 species, with 47 new additions. The database has been updated with rate coefficients for all reaction types, including 1171 new anion reactions and updated photorates. New features include state-specific deuterated rate coefficients, deuterium exchange reactions, and surface binding energies for many neutral species. The authors have tested the main reaction network using dark cloud and carbon-rich circumstellar envelope models, demonstrating its applicability to various astrophysical environments. The paper discusses the improvements in the new version, such as the inclusion of anion reactions and updated dissociative recombination rates, and compares the results with observations of TMC-1 and IRC+10216. The models show reasonable agreement with observations, highlighting the importance of accurate rate coefficients, especially at low temperatures. The paper also discusses the impact of anions on the chemistry in circumstellar envelopes, showing how they affect the ionization balance and the abundances of various species.