The fifth release of the UMIST Database for Astrochemistry (UDfA), known as RATE12, includes 6173 gas-phase reactions involving 467 species, with 47 new species. The database has been updated with new anion reactions, revised photorates, and state-specific deuterated rate coefficients, deuterium exchange reactions, and surface binding energies. The database now includes a singly-deuterated version of RATE12 and provides detailed information on reaction networks, including references to original data sources. The database is available for download and includes a new website with detailed reaction notes, InChI codes, and data source references. The database is part of the VAMDC project, which aims to provide a comprehensive, open, and flexible interface to atomic and molecular data. The database has been tested using dark cloud and carbon-rich circumstellar envelope models, showing good agreement with observations. The database includes updated reaction networks for various chemical processes, including dissociative recombination, neutral-neutral reactions, and cation-neutral reactions. The database also includes new data on surface binding energies and anion chemistry, which are important for modeling grain-surface chemistry. The database has been updated to include more accurate rate coefficients for various reactions, including those involving anions and deuterium. The database has been tested against observations of TMC-1 and IRC+10216, showing that it provides a reasonable approximation of the chemistry in these environments. The database is now available for download and includes a range of data and tools for users to explore and model astrochemical processes.The fifth release of the UMIST Database for Astrochemistry (UDfA), known as RATE12, includes 6173 gas-phase reactions involving 467 species, with 47 new species. The database has been updated with new anion reactions, revised photorates, and state-specific deuterated rate coefficients, deuterium exchange reactions, and surface binding energies. The database now includes a singly-deuterated version of RATE12 and provides detailed information on reaction networks, including references to original data sources. The database is available for download and includes a new website with detailed reaction notes, InChI codes, and data source references. The database is part of the VAMDC project, which aims to provide a comprehensive, open, and flexible interface to atomic and molecular data. The database has been tested using dark cloud and carbon-rich circumstellar envelope models, showing good agreement with observations. The database includes updated reaction networks for various chemical processes, including dissociative recombination, neutral-neutral reactions, and cation-neutral reactions. The database also includes new data on surface binding energies and anion chemistry, which are important for modeling grain-surface chemistry. The database has been updated to include more accurate rate coefficients for various reactions, including those involving anions and deuterium. The database has been tested against observations of TMC-1 and IRC+10216, showing that it provides a reasonable approximation of the chemistry in these environments. The database is now available for download and includes a range of data and tools for users to explore and model astrochemical processes.