The article provides a comprehensive overview of the Wnt signaling pathway, its components, and its roles in development and disease. Wnt proteins, a family of secreted signaling molecules, play crucial roles in embryogenesis and adult tissue maintenance. The canonical Wnt signaling pathway involves the binding of Wnt proteins to Frizzled (Fz) receptors, which activate Dishevelled (Dsh) and other intracellular proteins, leading to the stabilization and nuclear translocation of β-catenin. β-catenin then interacts with transcription factors like LEF/TCF to regulate gene expression. The article discusses the lipid modification of Wnt proteins, their transport between cells, and the interaction of Wnt receptors with extracellular inhibitors. It also explores the cytoplasmic and nuclear components of the Wnt signaling pathway, including the role of Axin and GSK-3 in β-catenin degradation and the regulation of target genes by β-catenin. The article highlights the importance of Wnt signaling in various biological processes, such as cell proliferation, cell adhesion, and stem cell regulation, and its implications in human diseases like cancer and degenerative disorders. Finally, it touches on the evolutionary origins of Wnt signaling and the potential therapeutic applications of manipulating Wnt signaling.The article provides a comprehensive overview of the Wnt signaling pathway, its components, and its roles in development and disease. Wnt proteins, a family of secreted signaling molecules, play crucial roles in embryogenesis and adult tissue maintenance. The canonical Wnt signaling pathway involves the binding of Wnt proteins to Frizzled (Fz) receptors, which activate Dishevelled (Dsh) and other intracellular proteins, leading to the stabilization and nuclear translocation of β-catenin. β-catenin then interacts with transcription factors like LEF/TCF to regulate gene expression. The article discusses the lipid modification of Wnt proteins, their transport between cells, and the interaction of Wnt receptors with extracellular inhibitors. It also explores the cytoplasmic and nuclear components of the Wnt signaling pathway, including the role of Axin and GSK-3 in β-catenin degradation and the regulation of target genes by β-catenin. The article highlights the importance of Wnt signaling in various biological processes, such as cell proliferation, cell adhesion, and stem cell regulation, and its implications in human diseases like cancer and degenerative disorders. Finally, it touches on the evolutionary origins of Wnt signaling and the potential therapeutic applications of manipulating Wnt signaling.