The article discusses the zinc finger-containing transcription factors GATA-4, -5, and -6, which are highly conserved proteins with a DNA binding domain consisting of two zinc fingers. These factors are divided into two subfamilies based on their expression patterns: GATA-1, -2, and -3 are primarily expressed in hematopoietic stem cells, while GATA-4, -5, and -6 are expressed in various mesodermal and endodermal tissues. The article highlights the biochemical characteristics and transcriptional regulatory roles of these factors, including their structure-function analysis, expression patterns, and gene targeting in mice. It also explores their roles in tissue-specific gene expression, inducible gene expression, and interactions with other transcription factors. The findings suggest that GATA-4, -5, and -6 play crucial roles in regulating gene expression in heart, liver, gonad, gut epithelium, and lung, and that their tissue-specific functions may be mediated through interactions with other transcription factors.The article discusses the zinc finger-containing transcription factors GATA-4, -5, and -6, which are highly conserved proteins with a DNA binding domain consisting of two zinc fingers. These factors are divided into two subfamilies based on their expression patterns: GATA-1, -2, and -3 are primarily expressed in hematopoietic stem cells, while GATA-4, -5, and -6 are expressed in various mesodermal and endodermal tissues. The article highlights the biochemical characteristics and transcriptional regulatory roles of these factors, including their structure-function analysis, expression patterns, and gene targeting in mice. It also explores their roles in tissue-specific gene expression, inducible gene expression, and interactions with other transcription factors. The findings suggest that GATA-4, -5, and -6 play crucial roles in regulating gene expression in heart, liver, gonad, gut epithelium, and lung, and that their tissue-specific functions may be mediated through interactions with other transcription factors.