The article discusses the maintenance and updates of the Carbohydrate-Active Enzyme (CAZy) database, which has been a valuable resource for analyzing and understanding the ability of organisms to assemble and break down complex carbohydrates. The CAZy database, freely available at www.cazy.org, is maintained through a combination of automated and manual curation. The primary tasks of the curators include maintaining and updating the family classification, classifying newly released sequences, and capturing functional information for each family. The database has seen significant growth over the past 20 years, with an increase in the number of CAZymes listed, particularly in carbohydrate-binding modules (CBMs) and polysaccharide lyases (PLs). The authors highlight the importance of human curation in identifying and adjusting criteria for distant relatives of CAZymes, which are crucial for functional exploration. They also describe new features on the CAZy website, such as a form for reporting functional characterizations, improved taxonomic navigation, and the integration of literature references for functional annotations. These changes aim to enhance the accessibility and utility of the database for the scientific community.The article discusses the maintenance and updates of the Carbohydrate-Active Enzyme (CAZy) database, which has been a valuable resource for analyzing and understanding the ability of organisms to assemble and break down complex carbohydrates. The CAZy database, freely available at www.cazy.org, is maintained through a combination of automated and manual curation. The primary tasks of the curators include maintaining and updating the family classification, classifying newly released sequences, and capturing functional information for each family. The database has seen significant growth over the past 20 years, with an increase in the number of CAZymes listed, particularly in carbohydrate-binding modules (CBMs) and polysaccharide lyases (PLs). The authors highlight the importance of human curation in identifying and adjusting criteria for distant relatives of CAZymes, which are crucial for functional exploration. They also describe new features on the CAZy website, such as a form for reporting functional characterizations, improved taxonomic navigation, and the integration of literature references for functional annotations. These changes aim to enhance the accessibility and utility of the database for the scientific community.