The Carbohydrate-Active Enzymes (CAZy) database has been maintained for over 20 years, providing a comprehensive resource for carbohydrate-active enzymes. The database is curated by a team of scientists and includes information on enzyme families, their functions, and biochemical data. The CAZy database is updated monthly and has grown significantly over the past 8 years, with the number of CAZymes listed increasing by 6.7 times. The database includes information on various enzyme families, such as glycoside hydrolases (GH), glycosyltransferases (GT), polysaccharide lyases (PL), carbohydrate esterases (CE), auxiliary activities (AA), and carbohydrate-binding modules (CBM). The database also includes functional annotations based on literature and biochemical data. The CAZy database is essential for understanding the ability of organisms to break down complex carbohydrates. The database is maintained through a combination of automated and manual curation, with a focus on ensuring the accuracy and reliability of the data. The database has also been updated to include new features, such as improved display of information and enhanced access to genome data. The CAZy database is a valuable resource for researchers in the field of carbohydrate biochemistry and biotechnology.The Carbohydrate-Active Enzymes (CAZy) database has been maintained for over 20 years, providing a comprehensive resource for carbohydrate-active enzymes. The database is curated by a team of scientists and includes information on enzyme families, their functions, and biochemical data. The CAZy database is updated monthly and has grown significantly over the past 8 years, with the number of CAZymes listed increasing by 6.7 times. The database includes information on various enzyme families, such as glycoside hydrolases (GH), glycosyltransferases (GT), polysaccharide lyases (PL), carbohydrate esterases (CE), auxiliary activities (AA), and carbohydrate-binding modules (CBM). The database also includes functional annotations based on literature and biochemical data. The CAZy database is essential for understanding the ability of organisms to break down complex carbohydrates. The database is maintained through a combination of automated and manual curation, with a focus on ensuring the accuracy and reliability of the data. The database has also been updated to include new features, such as improved display of information and enhanced access to genome data. The CAZy database is a valuable resource for researchers in the field of carbohydrate biochemistry and biotechnology.