The Carbohydrate-Active Enzymes database (CAZy) was launched in 1999 to provide online access to a sequence-based family classification of carbohydrate-active enzymes (CAZymes). It has grown significantly over the past five years, with over 340,000 CAZymes reported, a 225% increase from five years ago. The database now includes over 2,800 genomes from various kingdoms, with a focus on carbohydrate-active enzymes (CAZomes) that provide insights into the metabolism of complex carbohydrates. The CAZy database also includes structural information, such as 3D structures and carbohydrate ligands, which are crucial for understanding enzyme function. The database has been updated to include new families, subfamilies, and a more detailed classification system. The CAZy database is an essential resource for researchers studying carbohydrate-active enzymes, providing a comprehensive and curated database of sequence, structure, and function. The database has been expanded to include new enzyme classes, such as the 'Auxiliary Activities' class, which encompasses enzymes involved in lignocellulose conversion. The database also includes a variety of tools for searching and analyzing CAZymes, including a search tool that allows users to search the entire database or specific fields. The CAZy database is continuously updated and maintained by a team of experts, ensuring that it remains a reliable and comprehensive resource for the study of carbohydrate-active enzymes.The Carbohydrate-Active Enzymes database (CAZy) was launched in 1999 to provide online access to a sequence-based family classification of carbohydrate-active enzymes (CAZymes). It has grown significantly over the past five years, with over 340,000 CAZymes reported, a 225% increase from five years ago. The database now includes over 2,800 genomes from various kingdoms, with a focus on carbohydrate-active enzymes (CAZomes) that provide insights into the metabolism of complex carbohydrates. The CAZy database also includes structural information, such as 3D structures and carbohydrate ligands, which are crucial for understanding enzyme function. The database has been updated to include new families, subfamilies, and a more detailed classification system. The CAZy database is an essential resource for researchers studying carbohydrate-active enzymes, providing a comprehensive and curated database of sequence, structure, and function. The database has been expanded to include new enzyme classes, such as the 'Auxiliary Activities' class, which encompasses enzymes involved in lignocellulose conversion. The database also includes a variety of tools for searching and analyzing CAZymes, including a search tool that allows users to search the entire database or specific fields. The CAZy database is continuously updated and maintained by a team of experts, ensuring that it remains a reliable and comprehensive resource for the study of carbohydrate-active enzymes.