Aurora kinases are a family of highly conserved serine/threonine protein kinases essential for cell division. They regulate processes such as centrosome function, chromosome condensation, spindle dynamics, kinetochore-microtubule interactions, and cytokinesis. In mammals, there are three Aurora kinases: Aurora A, B, and C. Aurora A is associated with centrosomes and microtubules, while Aurora B is a chromosomal passenger protein involved in chromosome alignment and spindle-assembly checkpoint signaling. Aurora C is expressed in testes and localizes to the centrosome during anaphase to telophase. Aurora kinases are involved in various cellular processes, including chromosome segregation, spindle assembly, and cytokinesis. Their dysregulation can lead to cancer. Aurora A is particularly important for centrosome duplication and spindle assembly, and its overexpression can cause centrosome amplification and mitotic abnormalities. Aurora B is essential for chromosome condensation, kinetochore function, and the spindle-assembly checkpoint. Aurora C is involved in spindle assembly and cytokinesis. Aurora kinases are regulated by phosphorylation, association with proteins like TPX2, and degradation by the APC/C. Aurora A is regulated by phosphorylation at Thr295, which is essential for its activity. Aurora B is regulated by phosphorylation of its IN-box and by association with INCENP and survivin. Aurora C is less studied but is involved in spindle assembly and cytokinesis. Aurora kinases are potential targets for cancer therapy due to their role in cell division. Inhibitors of Aurora kinases, such as ZM447439 and hesperadin, have been developed and show promise in targeting cancer cells. These inhibitors disrupt spindle assembly and chromosome alignment, leading to cell death. Aurora kinases are also involved in the spindle-assembly checkpoint, which ensures proper chromosome alignment before anaphase. Their dysregulation can lead to aneuploidy and cancer. Aurora kinases are essential for proper cell division and are involved in various cellular processes. Their dysregulation can lead to cancer, and they are potential targets for cancer therapy. Understanding the roles and regulation of Aurora kinases is crucial for developing new treatments for cancer.Aurora kinases are a family of highly conserved serine/threonine protein kinases essential for cell division. They regulate processes such as centrosome function, chromosome condensation, spindle dynamics, kinetochore-microtubule interactions, and cytokinesis. In mammals, there are three Aurora kinases: Aurora A, B, and C. Aurora A is associated with centrosomes and microtubules, while Aurora B is a chromosomal passenger protein involved in chromosome alignment and spindle-assembly checkpoint signaling. Aurora C is expressed in testes and localizes to the centrosome during anaphase to telophase. Aurora kinases are involved in various cellular processes, including chromosome segregation, spindle assembly, and cytokinesis. Their dysregulation can lead to cancer. Aurora A is particularly important for centrosome duplication and spindle assembly, and its overexpression can cause centrosome amplification and mitotic abnormalities. Aurora B is essential for chromosome condensation, kinetochore function, and the spindle-assembly checkpoint. Aurora C is involved in spindle assembly and cytokinesis. Aurora kinases are regulated by phosphorylation, association with proteins like TPX2, and degradation by the APC/C. Aurora A is regulated by phosphorylation at Thr295, which is essential for its activity. Aurora B is regulated by phosphorylation of its IN-box and by association with INCENP and survivin. Aurora C is less studied but is involved in spindle assembly and cytokinesis. Aurora kinases are potential targets for cancer therapy due to their role in cell division. Inhibitors of Aurora kinases, such as ZM447439 and hesperadin, have been developed and show promise in targeting cancer cells. These inhibitors disrupt spindle assembly and chromosome alignment, leading to cell death. Aurora kinases are also involved in the spindle-assembly checkpoint, which ensures proper chromosome alignment before anaphase. Their dysregulation can lead to aneuploidy and cancer. Aurora kinases are essential for proper cell division and are involved in various cellular processes. Their dysregulation can lead to cancer, and they are potential targets for cancer therapy. Understanding the roles and regulation of Aurora kinases is crucial for developing new treatments for cancer.