The article explores the relationship between the membrane potential ($V_m$) and the zeta potential ($\zeta$), which is the electrical potential measured a few nanometers from the cell surface. While $V_m$ is typically described as arising from diffusion currents across a membrane with a constant electric field, recent evidence suggests that $V_m$ can also influence the $\zeta$-potential. This influence allows cells to dynamically alter their interactions with charged entities in their environment, including ions, molecules, and other cells. The review collates data from multiple studies on $V_m$ and $\zeta$-potential, showing that changes in $V_m$ can modulate $\zeta$-potential in various cell types, such as red blood cells, macrophages, platelets, sperm, ova, bacteria, and cancer cells. These findings suggest that $V_m$-mediated $\zeta$-potential plays a significant role in cell physiology and activity, including blood cell function, immune response, developmental biology, and cancer. The review also discusses the implications of these findings for understanding the role of electrical potentials and charges in regulating cell function and interactions with the environment.The article explores the relationship between the membrane potential ($V_m$) and the zeta potential ($\zeta$), which is the electrical potential measured a few nanometers from the cell surface. While $V_m$ is typically described as arising from diffusion currents across a membrane with a constant electric field, recent evidence suggests that $V_m$ can also influence the $\zeta$-potential. This influence allows cells to dynamically alter their interactions with charged entities in their environment, including ions, molecules, and other cells. The review collates data from multiple studies on $V_m$ and $\zeta$-potential, showing that changes in $V_m$ can modulate $\zeta$-potential in various cell types, such as red blood cells, macrophages, platelets, sperm, ova, bacteria, and cancer cells. These findings suggest that $V_m$-mediated $\zeta$-potential plays a significant role in cell physiology and activity, including blood cell function, immune response, developmental biology, and cancer. The review also discusses the implications of these findings for understanding the role of electrical potentials and charges in regulating cell function and interactions with the environment.