The article by Henry F. Chambers discusses the changing epidemiology of methicillin-resistant *Staphylococcus aureus* (MRSA), highlighting its emergence in the community and the potential for increased prevalence. Traditionally, MRSA infections have been confined to hospitals and long-term care facilities, but recent reports suggest that community-acquired MRSA strains are becoming more common. These community strains often lack resistance to multiple antibiotics, unlike hospital strains, and have distinct pulsed-field gel electrophoresis (PFGE) patterns. The author draws parallels between the emergence of MRSA and the historical development of penicillinase-producing *S. aureus* in the 1940s and 1950s, where resistance initially occurred in hospitals but later spread to the community. The origins of community-acquired MRSA are debated, with possibilities including feral descendants of hospital isolates or horizontal transfer of the methicillin-resistance determinant. The increasing prevalence of MRSA in the community poses significant clinical challenges, including treatment failure, complications, and the need for alternative antibiotics like vancomycin. Minimizing antibiotic pressure is crucial to controlling the emergence of resistant strains in both hospitals and communities.The article by Henry F. Chambers discusses the changing epidemiology of methicillin-resistant *Staphylococcus aureus* (MRSA), highlighting its emergence in the community and the potential for increased prevalence. Traditionally, MRSA infections have been confined to hospitals and long-term care facilities, but recent reports suggest that community-acquired MRSA strains are becoming more common. These community strains often lack resistance to multiple antibiotics, unlike hospital strains, and have distinct pulsed-field gel electrophoresis (PFGE) patterns. The author draws parallels between the emergence of MRSA and the historical development of penicillinase-producing *S. aureus* in the 1940s and 1950s, where resistance initially occurred in hospitals but later spread to the community. The origins of community-acquired MRSA are debated, with possibilities including feral descendants of hospital isolates or horizontal transfer of the methicillin-resistance determinant. The increasing prevalence of MRSA in the community poses significant clinical challenges, including treatment failure, complications, and the need for alternative antibiotics like vancomycin. Minimizing antibiotic pressure is crucial to controlling the emergence of resistant strains in both hospitals and communities.