The article provides a comprehensive overview of the complete genome sequence of *Helicobacter pylori* strain 26695, detailing its genetic makeup, regulatory mechanisms, and metabolic pathways. The genome consists of a circular chromosome with 1,667,867 base pairs and 1,590 predicted coding sequences. Key features include well-developed systems for motility, iron scavenging, and DNA restriction and modification. The presence of numerous outer membrane proteins suggests complex host-pathogen interactions. The article also discusses the mechanisms of antigenic variation, acid tolerance, and virulence, highlighting the role of specific genes and proteins. Additionally, it explores the evolutionary relationships of *H. pylori* with other bacteria and its potential for lateral gene transfer. The availability of the complete genome sequence will facilitate further research on *H. pylori* genetic diversity and its impact on disease outcomes.The article provides a comprehensive overview of the complete genome sequence of *Helicobacter pylori* strain 26695, detailing its genetic makeup, regulatory mechanisms, and metabolic pathways. The genome consists of a circular chromosome with 1,667,867 base pairs and 1,590 predicted coding sequences. Key features include well-developed systems for motility, iron scavenging, and DNA restriction and modification. The presence of numerous outer membrane proteins suggests complex host-pathogen interactions. The article also discusses the mechanisms of antigenic variation, acid tolerance, and virulence, highlighting the role of specific genes and proteins. Additionally, it explores the evolutionary relationships of *H. pylori* with other bacteria and its potential for lateral gene transfer. The availability of the complete genome sequence will facilitate further research on *H. pylori* genetic diversity and its impact on disease outcomes.