brenton graveley presented a talk on the developmental transcriptome of drosophila melanogaster at the "from beyond the genome: the true gene count, human evolution and disease genomics" conference in boston, ma, usa, on 11-13 october 2010. he discussed the ongoing research into the genome of this well-studied metazoan organism, highlighting that despite extensive study, the genome still contains unannotated genes, exons, and rna editing sites. graveley's team used rna-seq, tiling microarrays, and cdna sequencing to analyze the transcriptome across 30 developmental stages. they identified 87,352 new features, including thousands of genes, coding and non-coding transcripts, exons, splicing, and editing events. the study also inferred protein isoforms that were previously undetectable using traditional methods. these findings significantly expand the known transcribed elements in the drosophila genome and offer a high-resolution view of transcriptome dynamics during development. the research underscores the complexity of gene regulation in drosophila, particularly in transcription, splicing, and rna editing, which are crucial for its development. the presentation emphasized the importance of continued research into the transcriptome to better understand gene function and regulation in complex organisms. the work was published in 2010 and highlights the value of large-scale transcriptomic studies in advancing our understanding of genetic mechanisms. the talk also encouraged further research in this area, emphasizing the potential for new discoveries in gene function and disease genomics.brenton graveley presented a talk on the developmental transcriptome of drosophila melanogaster at the "from beyond the genome: the true gene count, human evolution and disease genomics" conference in boston, ma, usa, on 11-13 october 2010. he discussed the ongoing research into the genome of this well-studied metazoan organism, highlighting that despite extensive study, the genome still contains unannotated genes, exons, and rna editing sites. graveley's team used rna-seq, tiling microarrays, and cdna sequencing to analyze the transcriptome across 30 developmental stages. they identified 87,352 new features, including thousands of genes, coding and non-coding transcripts, exons, splicing, and editing events. the study also inferred protein isoforms that were previously undetectable using traditional methods. these findings significantly expand the known transcribed elements in the drosophila genome and offer a high-resolution view of transcriptome dynamics during development. the research underscores the complexity of gene regulation in drosophila, particularly in transcription, splicing, and rna editing, which are crucial for its development. the presentation emphasized the importance of continued research into the transcriptome to better understand gene function and regulation in complex organisms. the work was published in 2010 and highlights the value of large-scale transcriptomic studies in advancing our understanding of genetic mechanisms. the talk also encouraged further research in this area, emphasizing the potential for new discoveries in gene function and disease genomics.