Jul 2023, Pékin, China | Mado Abraham, Sylvain Feruglio, Ahmed Hamraoui, Hakeim Talleb, Vincent Vivier, Kieu Ngo
This study aims to fabricate a biomaterial that closely mimics the dielectric properties of bone, particularly for spinal surgery where low-frequency electrical stimulation is used to verify the placement of titanium pedicle screws around nerve structures. The researchers prepared different mixtures of hydrogels containing chitosan and hydroxyapatite (HAp) by varying their concentrations and pH levels. Electrochemical impedance spectroscopy (EIS) measurements were conducted to determine the electrical properties of these hydrogels from 1 Hz to 1 MHz. The results showed that hydrogels with 5mg/ml chitosan exhibited electrical properties similar to cancellous bone. This work provides a foundation for developing tissue-mimicking materials that can be used in medical applications such as surgical procedures, medical imaging, and simulations.This study aims to fabricate a biomaterial that closely mimics the dielectric properties of bone, particularly for spinal surgery where low-frequency electrical stimulation is used to verify the placement of titanium pedicle screws around nerve structures. The researchers prepared different mixtures of hydrogels containing chitosan and hydroxyapatite (HAp) by varying their concentrations and pH levels. Electrochemical impedance spectroscopy (EIS) measurements were conducted to determine the electrical properties of these hydrogels from 1 Hz to 1 MHz. The results showed that hydrogels with 5mg/ml chitosan exhibited electrical properties similar to cancellous bone. This work provides a foundation for developing tissue-mimicking materials that can be used in medical applications such as surgical procedures, medical imaging, and simulations.