A meta-analysis of 39 studies involving 1,140 participants found that mindfulness-based therapy (MBT) is moderately effective in reducing anxiety and depression symptoms. The effect size for anxiety was Hedges’ g = 0.63, and for depression, Hedges’ g = 0.59. In patients with anxiety and mood disorders, the effect sizes were 0.97 and 0.95, respectively. These effects were robust and not influenced by publication year or treatment duration. Follow-up data showed sustained benefits. MBT was effective across various conditions, including cancer, generalized anxiety disorder, and depression. The study also found that MBT was effective in reducing symptoms in individuals without a clinical diagnosis of anxiety or mood disorders, suggesting broad applicability. However, controlled studies showed less consistent results, and the findings should be interpreted cautiously. The results suggest that MBT is a promising intervention for treating anxiety and mood problems in clinical populations. The study highlights the need for further research to compare MBT with conventional CBT and to address limitations such as publication bias and study quality. Overall, the findings support the use of MBT for anxiety and depression in clinical settings.A meta-analysis of 39 studies involving 1,140 participants found that mindfulness-based therapy (MBT) is moderately effective in reducing anxiety and depression symptoms. The effect size for anxiety was Hedges’ g = 0.63, and for depression, Hedges’ g = 0.59. In patients with anxiety and mood disorders, the effect sizes were 0.97 and 0.95, respectively. These effects were robust and not influenced by publication year or treatment duration. Follow-up data showed sustained benefits. MBT was effective across various conditions, including cancer, generalized anxiety disorder, and depression. The study also found that MBT was effective in reducing symptoms in individuals without a clinical diagnosis of anxiety or mood disorders, suggesting broad applicability. However, controlled studies showed less consistent results, and the findings should be interpreted cautiously. The results suggest that MBT is a promising intervention for treating anxiety and mood problems in clinical populations. The study highlights the need for further research to compare MBT with conventional CBT and to address limitations such as publication bias and study quality. Overall, the findings support the use of MBT for anxiety and depression in clinical settings.