The article provides an overview of the epidemiology of pancreatitis and pancreatic cancer, highlighting their incidence, prevalence, and trends. Acute pancreatitis (AP) is the most frequent gastrointestinal cause of hospital admissions in the US, while chronic pancreatitis (CP) significantly impacts patients' quality of life. Pancreatic cancer has a high mortality rate and is one of the top five causes of cancer-related deaths. The burden of these disorders is expected to increase over time. Risk factors for pancreatitis and pancreatic cancer vary with age and sex, with Blacks being more affected than other races. Gallstones are the primary cause of AP, and early cholecystectomy can prevent future attacks. Alcohol is the most significant risk factor for chronic pancreatitis, and smoking is an independent risk factor for both acute and chronic pancreatitis. Significant risk factors for pancreatic cancer include smoking and non-O blood groups. Abstinence from alcohol and smoking cessation can reduce the progression and recurrence of pancreatitis and lower the risk of pancreatic cancer. The article also discusses the role of diet, obesity, diabetes, drug exposure, and blood type in the epidemiology of these disorders.The article provides an overview of the epidemiology of pancreatitis and pancreatic cancer, highlighting their incidence, prevalence, and trends. Acute pancreatitis (AP) is the most frequent gastrointestinal cause of hospital admissions in the US, while chronic pancreatitis (CP) significantly impacts patients' quality of life. Pancreatic cancer has a high mortality rate and is one of the top five causes of cancer-related deaths. The burden of these disorders is expected to increase over time. Risk factors for pancreatitis and pancreatic cancer vary with age and sex, with Blacks being more affected than other races. Gallstones are the primary cause of AP, and early cholecystectomy can prevent future attacks. Alcohol is the most significant risk factor for chronic pancreatitis, and smoking is an independent risk factor for both acute and chronic pancreatitis. Significant risk factors for pancreatic cancer include smoking and non-O blood groups. Abstinence from alcohol and smoking cessation can reduce the progression and recurrence of pancreatitis and lower the risk of pancreatic cancer. The article also discusses the role of diet, obesity, diabetes, drug exposure, and blood type in the epidemiology of these disorders.