Long intergenic non-coding RNAs (lincRNAs) are non-coding RNAs longer than 200 nucleotides that do not overlap annotated coding genes. They are distinct from other long non-coding RNAs (lncRNAs) and constitute more than half of lincRNA transcripts in humans. LincRNAs are not evolutionarily neutral and show greater conservation than ancient repeat sequences but less than protein-coding genes. They are involved in various functions, including chromatin remodeling, RNA stabilization, and transcription regulation. LincRNAs may fine-tune the expression of neighboring genes with remarkable tissue specificity through diverse mechanisms. LincRNAs differ from mRNAs in abundance, genomic localization, subcellular localization, metabolic profiles, epigenetic regulation, and tissue specificity. They are more often located in the nucleus than in the cytoplasm. LincRNAs have fewer exons, are shorter, and are expressed at a lower level than mRNAs. They are also less conserved than protein-coding genes but may have species-specific functions. LincRNAs can regulate gene expression by interacting with chromatin-modifying complexes, influencing epigenetic landscapes. They can also act as scaffolds for proteins and other RNAs, or as decoys for proteins, mRNAs, and miRNAs. LincRNAs can regulate neighboring genes and produce micropeptides. Some lincRNAs contain small open reading frames (smORFs) that encode functional peptides. LincRNAs may also influence splicing of other RNAs by interacting with splicing factors or masking splicing signals. They can affect the stability and degradation of transcripts through various mechanisms, including ribosome association, microRNA binding, and RNA-binding protein interactions. LincRNAs are involved in tissue-specific functions and developmental patterning. They can regulate the expression of genes in a tissue-specific manner and may be involved in the regulation of chromatin architecture. LincRNAs may also play a role in the maintenance of lncRNA expression through interactions with miRNA and MYC circuitry. LincRNAs have diverse functions, including regulating chromatin topology, scaffolding proteins and other RNAs, acting as decoys, and producing micropeptides. They may also be involved in the regulation of gene expression through interactions with enhancer elements and chromatin-modifying complexes. LincRNAs may have both coding and non-coding functions, with some containing smORFs that encode functional peptides. The functions of lincRNAs are still being explored, and their roles in various biological processes are an active area of research.Long intergenic non-coding RNAs (lincRNAs) are non-coding RNAs longer than 200 nucleotides that do not overlap annotated coding genes. They are distinct from other long non-coding RNAs (lncRNAs) and constitute more than half of lincRNA transcripts in humans. LincRNAs are not evolutionarily neutral and show greater conservation than ancient repeat sequences but less than protein-coding genes. They are involved in various functions, including chromatin remodeling, RNA stabilization, and transcription regulation. LincRNAs may fine-tune the expression of neighboring genes with remarkable tissue specificity through diverse mechanisms. LincRNAs differ from mRNAs in abundance, genomic localization, subcellular localization, metabolic profiles, epigenetic regulation, and tissue specificity. They are more often located in the nucleus than in the cytoplasm. LincRNAs have fewer exons, are shorter, and are expressed at a lower level than mRNAs. They are also less conserved than protein-coding genes but may have species-specific functions. LincRNAs can regulate gene expression by interacting with chromatin-modifying complexes, influencing epigenetic landscapes. They can also act as scaffolds for proteins and other RNAs, or as decoys for proteins, mRNAs, and miRNAs. LincRNAs can regulate neighboring genes and produce micropeptides. Some lincRNAs contain small open reading frames (smORFs) that encode functional peptides. LincRNAs may also influence splicing of other RNAs by interacting with splicing factors or masking splicing signals. They can affect the stability and degradation of transcripts through various mechanisms, including ribosome association, microRNA binding, and RNA-binding protein interactions. LincRNAs are involved in tissue-specific functions and developmental patterning. They can regulate the expression of genes in a tissue-specific manner and may be involved in the regulation of chromatin architecture. LincRNAs may also play a role in the maintenance of lncRNA expression through interactions with miRNA and MYC circuitry. LincRNAs have diverse functions, including regulating chromatin topology, scaffolding proteins and other RNAs, acting as decoys, and producing micropeptides. They may also be involved in the regulation of gene expression through interactions with enhancer elements and chromatin-modifying complexes. LincRNAs may have both coding and non-coding functions, with some containing smORFs that encode functional peptides. The functions of lincRNAs are still being explored, and their roles in various biological processes are an active area of research.