The study identified a gene, ALOX5AP, encoding 5-lipoxygenase activating protein (FLAP), which is associated with an increased risk of myocardial infarction and stroke. A four-marker single-nucleotide polymorphism (SNP) haplotype in this gene spans 33 kb and is carried by 29.1% of individuals with myocardial infarction, conferring a nearly two times greater risk of myocardial infarction and stroke. This haplotype is more prevalent in males and is associated with increased production of leukotriene B4 (LTB4) in stimulated neutrophils, particularly in males. The study also found that another ALOX5AP haplotype is associated with myocardial infarction in a British cohort. These findings suggest that variants of ALOX5AP are involved in the pathogenesis of myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.The study identified a gene, ALOX5AP, encoding 5-lipoxygenase activating protein (FLAP), which is associated with an increased risk of myocardial infarction and stroke. A four-marker single-nucleotide polymorphism (SNP) haplotype in this gene spans 33 kb and is carried by 29.1% of individuals with myocardial infarction, conferring a nearly two times greater risk of myocardial infarction and stroke. This haplotype is more prevalent in males and is associated with increased production of leukotriene B4 (LTB4) in stimulated neutrophils, particularly in males. The study also found that another ALOX5AP haplotype is associated with myocardial infarction in a British cohort. These findings suggest that variants of ALOX5AP are involved in the pathogenesis of myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall.