A systematic review of global literature estimates that pesticide self-poisoning accounts for about one-third of global suicides, with 258,234 deaths annually (range 233,997 to 325,907). This represents 30% (27% to 37%) of all suicides worldwide. The study highlights that pesticide use is a major contributor to suicide, particularly in regions with high pesticide availability and toxicity. The proportion of suicides involving pesticides varies widely by region, ranging from 4% in Europe to over 50% in the Western Pacific. However, this variation is not directly linked to pesticide sales but rather to patterns of use and product toxicity. The study emphasizes that restricting access to highly toxic pesticides, improving safe storage, and enhancing access to quality healthcare for poisoning cases could prevent many deaths. India's official suicide data are considered under-estimated, and adjusting for this increases the global pesticide suicide estimate to 371,594. The review also notes that pesticide self-poisoning is more common in rural areas, where healthcare resources are often limited. The findings underscore the need for urgent policy action to address pesticide-related suicides, including improved access to healthcare, safer pesticide storage, and restrictions on the sale of highly toxic pesticides. The study concludes that pesticide poisoning is a significant public health issue requiring targeted interventions to reduce its impact.A systematic review of global literature estimates that pesticide self-poisoning accounts for about one-third of global suicides, with 258,234 deaths annually (range 233,997 to 325,907). This represents 30% (27% to 37%) of all suicides worldwide. The study highlights that pesticide use is a major contributor to suicide, particularly in regions with high pesticide availability and toxicity. The proportion of suicides involving pesticides varies widely by region, ranging from 4% in Europe to over 50% in the Western Pacific. However, this variation is not directly linked to pesticide sales but rather to patterns of use and product toxicity. The study emphasizes that restricting access to highly toxic pesticides, improving safe storage, and enhancing access to quality healthcare for poisoning cases could prevent many deaths. India's official suicide data are considered under-estimated, and adjusting for this increases the global pesticide suicide estimate to 371,594. The review also notes that pesticide self-poisoning is more common in rural areas, where healthcare resources are often limited. The findings underscore the need for urgent policy action to address pesticide-related suicides, including improved access to healthcare, safer pesticide storage, and restrictions on the sale of highly toxic pesticides. The study concludes that pesticide poisoning is a significant public health issue requiring targeted interventions to reduce its impact.