The greatest Dengue epidemic in Brazil: Surveillance, Prevention, and Control

The greatest Dengue epidemic in Brazil: Surveillance, Prevention, and Control

2024 | Rodrigo Gurgel-Gonçalves, Wanderson Kleber de Oliveira, and Julio Croda
This review article discusses the surveillance, prevention, and control measures of dengue in Brazil, highlighting the significant increase in dengue cases and deaths between 2000 and 2024. The authors attribute this growth to global climate change, which has led to warmer temperatures and altered precipitation patterns, facilitating the expansion of *Aedes aegypti* mosquitoes. Over the past 25 years, nearly 18 million Brazilians have been infected with the dengue virus, and the highest number of cases in Brazilian history is projected to reach 2024. Dengue mortality has also increased geographically over time, with approximately 6 million probable cases and 4,000 confirmed deaths reported as of June 2024. Several technologies have been developed to control *Aedes aegypti*, including the deployment of *Wolbachia*-infected mosquitoes, indoor residual spraying, sterile insect techniques, and mosquito-disseminated insecticides. The Ministry of Health recommends integrating these technologies into health services. Brazil is the first country to incorporate the Takeda vaccine into its public health system, and the Butantan vaccine is currently undergoing Phase 3 clinical trials. The authors emphasize the importance of community activities such as home cleaning and eliminating potential mosquito breeding sites, facilitated by social media and health education initiatives. A multisectoral approach, encompassing sanitary improvements, mosquito control, vaccination, and community mobilization, is crucial in the fight against dengue epidemics. The review also highlights the need for continuous education and training to improve the diagnosis and clinical management of dengue in healthcare systems.This review article discusses the surveillance, prevention, and control measures of dengue in Brazil, highlighting the significant increase in dengue cases and deaths between 2000 and 2024. The authors attribute this growth to global climate change, which has led to warmer temperatures and altered precipitation patterns, facilitating the expansion of *Aedes aegypti* mosquitoes. Over the past 25 years, nearly 18 million Brazilians have been infected with the dengue virus, and the highest number of cases in Brazilian history is projected to reach 2024. Dengue mortality has also increased geographically over time, with approximately 6 million probable cases and 4,000 confirmed deaths reported as of June 2024. Several technologies have been developed to control *Aedes aegypti*, including the deployment of *Wolbachia*-infected mosquitoes, indoor residual spraying, sterile insect techniques, and mosquito-disseminated insecticides. The Ministry of Health recommends integrating these technologies into health services. Brazil is the first country to incorporate the Takeda vaccine into its public health system, and the Butantan vaccine is currently undergoing Phase 3 clinical trials. The authors emphasize the importance of community activities such as home cleaning and eliminating potential mosquito breeding sites, facilitated by social media and health education initiatives. A multisectoral approach, encompassing sanitary improvements, mosquito control, vaccination, and community mobilization, is crucial in the fight against dengue epidemics. The review also highlights the need for continuous education and training to improve the diagnosis and clinical management of dengue in healthcare systems.
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