The high-value and sustainable utilization of grape pomace: A review Grape pomace, the main by-product of winemaking, accounts for about 30% of the total material weight and is a rich source of bioactive substances, including polyphenols, flavonoids, anthocyanins, and dietary fiber. These components have significant health benefits, such as antioxidant, anti-inflammatory, and anti-cancer properties. However, the high-value recycling of grape pomace is hindered by social barriers, such as the acceptability of upcycled products. To achieve sustainability, green extraction methods are essential for recovering bioactive substances from grape pomace. Emerging technologies, such as supercritical fluid extraction and natural deep eutectic solvents, are being explored for their efficiency and environmental benefits. These methods offer advantages over traditional solvent extraction, including lower energy consumption, reduced solvent use, and higher purity of extracted compounds. Despite these advancements, challenges remain in scaling up these technologies and ensuring the safety and acceptability of upcycled products. The potential of grape pomace as a sustainable resource is significant, with applications in food, cosmetics, and pharmaceuticals. However, further research and development are needed to optimize extraction processes, reduce environmental impact, and promote the circular economy. The review highlights the importance of integrating technological innovations with social and economic considerations to achieve the sustainable utilization of grape pomace.The high-value and sustainable utilization of grape pomace: A review Grape pomace, the main by-product of winemaking, accounts for about 30% of the total material weight and is a rich source of bioactive substances, including polyphenols, flavonoids, anthocyanins, and dietary fiber. These components have significant health benefits, such as antioxidant, anti-inflammatory, and anti-cancer properties. However, the high-value recycling of grape pomace is hindered by social barriers, such as the acceptability of upcycled products. To achieve sustainability, green extraction methods are essential for recovering bioactive substances from grape pomace. Emerging technologies, such as supercritical fluid extraction and natural deep eutectic solvents, are being explored for their efficiency and environmental benefits. These methods offer advantages over traditional solvent extraction, including lower energy consumption, reduced solvent use, and higher purity of extracted compounds. Despite these advancements, challenges remain in scaling up these technologies and ensuring the safety and acceptability of upcycled products. The potential of grape pomace as a sustainable resource is significant, with applications in food, cosmetics, and pharmaceuticals. However, further research and development are needed to optimize extraction processes, reduce environmental impact, and promote the circular economy. The review highlights the importance of integrating technological innovations with social and economic considerations to achieve the sustainable utilization of grape pomace.