The study investigates the human gut virome, focusing on its composition and dynamics in response to dietary intervention. Longitudinal fecal samples from six healthy volunteers were analyzed using metagenomic sequencing of virus-like particles (VLP) and total microbial communities. The VLP sequences were assembled into 7175 contigs, many of which were identified as complete or partial bacteriophage genomes. The virome was found to be highly variable among individuals, with interpersonal variation being the primary source of variance. Dietary intervention led to significant changes in the virome community, with individuals on the same diet converging in their virome composition. The study also identified functional annotations such as CRISPR arrays and antibiotic resistance genes in the VLP contigs, suggesting potential roles in host-bacteriophage interactions and defense mechanisms. The results highlight the dynamic nature of the human gut virome and its response to dietary changes.The study investigates the human gut virome, focusing on its composition and dynamics in response to dietary intervention. Longitudinal fecal samples from six healthy volunteers were analyzed using metagenomic sequencing of virus-like particles (VLP) and total microbial communities. The VLP sequences were assembled into 7175 contigs, many of which were identified as complete or partial bacteriophage genomes. The virome was found to be highly variable among individuals, with interpersonal variation being the primary source of variance. Dietary intervention led to significant changes in the virome community, with individuals on the same diet converging in their virome composition. The study also identified functional annotations such as CRISPR arrays and antibiotic resistance genes in the VLP contigs, suggesting potential roles in host-bacteriophage interactions and defense mechanisms. The results highlight the dynamic nature of the human gut virome and its response to dietary changes.