2024 May 07; 36(5): 893–911. | Manish Mishra, Judy Wu, Alice E. Kane, Susan E. Howlett
The article explores the bidirectional relationship between frailty and metabolism, highlighting how metabolic interventions can mitigate frailty in older individuals. Frailty, characterized by rapid aging and increased risk of adverse health outcomes, is linked to metabolic dysregulation. The review discusses how dietary factors, such as undernutrition and overnutrition, impact frailty, and how metabolic diseases like metabolic syndrome (MetS) influence frailty. It also examines the impact of metabolic interventions, including dietary modifications, protein supplementation, and pharmacological treatments, on reducing frailty in both humans and animal models. The article suggests that maintaining a youthful metabolism may protect against frailty and that interventions targeting metabolic health could be crucial for preventing and managing frailty in older adults.The article explores the bidirectional relationship between frailty and metabolism, highlighting how metabolic interventions can mitigate frailty in older individuals. Frailty, characterized by rapid aging and increased risk of adverse health outcomes, is linked to metabolic dysregulation. The review discusses how dietary factors, such as undernutrition and overnutrition, impact frailty, and how metabolic diseases like metabolic syndrome (MetS) influence frailty. It also examines the impact of metabolic interventions, including dietary modifications, protein supplementation, and pharmacological treatments, on reducing frailty in both humans and animal models. The article suggests that maintaining a youthful metabolism may protect against frailty and that interventions targeting metabolic health could be crucial for preventing and managing frailty in older adults.