Vol. 12, No. 6 | Paul Zimmet1, Dianna Magliano1, Yuji Matsuzawa2, George Alberti3, Jonathan Shaw1
The metabolic syndrome, characterized by a cluster of abnormalities including central obesity, decreased HDL-C, elevated triglycerides, high blood pressure, and hyperglycemia, is a significant global public health issue. It is associated with a threefold and twofold increase in type 2 diabetes and cardiovascular disease (CVD), respectively, making it a major driver of modern epidemics. Over the years, various definitions of the metabolic syndrome have emerged, leading to inconsistencies and confusion in prevalence rates. The International Diabetes Federation (IDF) has recently proposed a new definition to address these issues, emphasizing central obesity and waist circumference as key components. This new definition aims to provide a more practical and globally applicable tool for identifying high-risk individuals and facilitating research. The IDF definition also includes criteria for central obesity that are ethnicity-specific, recognizing the importance of visceral fat accumulation. The article highlights the need for further research to identify additional components that could enhance the predictive value of the syndrome. Despite ongoing debates, the IDF's new definition is expected to help in the identification and management of individuals at risk for type 2 diabetes and CVD.The metabolic syndrome, characterized by a cluster of abnormalities including central obesity, decreased HDL-C, elevated triglycerides, high blood pressure, and hyperglycemia, is a significant global public health issue. It is associated with a threefold and twofold increase in type 2 diabetes and cardiovascular disease (CVD), respectively, making it a major driver of modern epidemics. Over the years, various definitions of the metabolic syndrome have emerged, leading to inconsistencies and confusion in prevalence rates. The International Diabetes Federation (IDF) has recently proposed a new definition to address these issues, emphasizing central obesity and waist circumference as key components. This new definition aims to provide a more practical and globally applicable tool for identifying high-risk individuals and facilitating research. The IDF definition also includes criteria for central obesity that are ethnicity-specific, recognizing the importance of visceral fat accumulation. The article highlights the need for further research to identify additional components that could enhance the predictive value of the syndrome. Despite ongoing debates, the IDF's new definition is expected to help in the identification and management of individuals at risk for type 2 diabetes and CVD.