**S54-5: Functional Asymmetries of the Brain in Schizophrenia** W.K. Strik, A. Heidrich, A.J. Fallgatter, Th.J. Mueller. Dept. of Psychiatry, University Hospital Warburg, Germany; Dept. of Psychology, University of Oregon, Eugene, USA Schizophrenic symptoms such as acoustic hallucinations and thought disorders are often related to speech, a function that is strongly lateralized in the brain and exclusive to humans. Neuropathological and imaging studies have shown alterations in left temporal areas in schizophrenia. Event-related potential (ERP) studies have revealed functional asymmetries in the P300 component of ERPs in schizophrenic patients. A subgroup of residual schizophrenics exhibited right-lateralized P300 peaks, which were correlated with impairments in verbal memory but not with abstract task performance. Source localization indicated relative hyperactivity in the right temporal lobe, supporting the hypothesis that language-related brain functions are deficient in certain subgroups of schizophrenia and may be associated with compensatory contralateral activation. **S54-6: EEG FFT Approximation Source Locations in Schizophrenia** T. Dierks, K. Maurer. Dept. of Psychiatry and Psychotherapy I, Univ. of Frankfurt/Main, Germany EEG FFT approximation allows the estimation of intracerebral EEG-generators in the frequency domain, providing a physiological interpretation of neurophysiological investigations. In a study comparing 22 schizophrenic patients to 22 control subjects, schizophrenic patients showed more anterior and superficial equivalent-dipoles in the beta bands and a tendency of increased beta-activity. The severity of symptoms was associated with more anterior beta1-band and more inferior theta-band dipole localization. These findings enhance the clinical relevance of EEG in psychiatry. **SEC55-1: The Mini International Neuropsychiatric Interview (MINI)** Y. Lecrubier, D. Sheehan, T. Hergueta, E. Weiller. INSERM U302, Pavillon Clérambault, Hôpital de la Salpêtrière, Paris, France The MINI is a short diagnostic structured interview that generates 17 DSM-IV or ICD-10 axis I diagnoses. It explores diagnostic criteria systematically within 10-25 minutes. The MINI's reliability, sensitivity, and specificity were comparable to longer interviews like the CIDI and SCID. A multicenter trial showed high concordance between general practitioners (GPs) using the MINI and specialized interviewers for the three most frequent diagnoses. The MINI is easy to use and has been translated into over 30 languages. A MINI plus version includes additional diagnoses and a full exploration of psychotic disorders. **SEC55-2: A Spanish Validation Study of the Mini International Neuropsychiatric Interview** J.**S54-5: Functional Asymmetries of the Brain in Schizophrenia** W.K. Strik, A. Heidrich, A.J. Fallgatter, Th.J. Mueller. Dept. of Psychiatry, University Hospital Warburg, Germany; Dept. of Psychology, University of Oregon, Eugene, USA Schizophrenic symptoms such as acoustic hallucinations and thought disorders are often related to speech, a function that is strongly lateralized in the brain and exclusive to humans. Neuropathological and imaging studies have shown alterations in left temporal areas in schizophrenia. Event-related potential (ERP) studies have revealed functional asymmetries in the P300 component of ERPs in schizophrenic patients. A subgroup of residual schizophrenics exhibited right-lateralized P300 peaks, which were correlated with impairments in verbal memory but not with abstract task performance. Source localization indicated relative hyperactivity in the right temporal lobe, supporting the hypothesis that language-related brain functions are deficient in certain subgroups of schizophrenia and may be associated with compensatory contralateral activation. **S54-6: EEG FFT Approximation Source Locations in Schizophrenia** T. Dierks, K. Maurer. Dept. of Psychiatry and Psychotherapy I, Univ. of Frankfurt/Main, Germany EEG FFT approximation allows the estimation of intracerebral EEG-generators in the frequency domain, providing a physiological interpretation of neurophysiological investigations. In a study comparing 22 schizophrenic patients to 22 control subjects, schizophrenic patients showed more anterior and superficial equivalent-dipoles in the beta bands and a tendency of increased beta-activity. The severity of symptoms was associated with more anterior beta1-band and more inferior theta-band dipole localization. These findings enhance the clinical relevance of EEG in psychiatry. **SEC55-1: The Mini International Neuropsychiatric Interview (MINI)** Y. Lecrubier, D. Sheehan, T. Hergueta, E. Weiller. INSERM U302, Pavillon Clérambault, Hôpital de la Salpêtrière, Paris, France The MINI is a short diagnostic structured interview that generates 17 DSM-IV or ICD-10 axis I diagnoses. It explores diagnostic criteria systematically within 10-25 minutes. The MINI's reliability, sensitivity, and specificity were comparable to longer interviews like the CIDI and SCID. A multicenter trial showed high concordance between general practitioners (GPs) using the MINI and specialized interviewers for the three most frequent diagnoses. The MINI is easy to use and has been translated into over 30 languages. A MINI plus version includes additional diagnoses and a full exploration of psychotic disorders. **SEC55-2: A Spanish Validation Study of the Mini International Neuropsychiatric Interview** J.