The article discusses the molecular logic of endocannabinoid signaling, focusing on the role of endocannabinoids in the brain. Endocannabinoids are lipid messengers that interact with cannabinoid receptors, such as CB1 and CB2, and are involved in various short-range signaling processes. They modulate synaptic efficacy and have therapeutic potential. The article traces the history of Cannabis, its discovery, and the identification of its active compound, THC. It describes the molecular cloning of CB1 and CB2 receptors and the subsequent discovery of endogenous ligands like anandamide and 2-AG. The article explains the biosynthesis, release, and deactivation of endocannabinoids, including their roles in synaptic plasticity, neurotransmission, and behavior. It also discusses the involvement of endocannabinoids in various brain functions, such as memory, emotion, motor activity, and pain regulation. The article highlights the therapeutic potential of endocannabinoids, particularly in the treatment of conditions like obesity and addiction. It also addresses the challenges in understanding the full mechanisms of endocannabinoid signaling, including the need for further research on their molecular pathways and interactions with other neurotransmitters. The article concludes with a discussion of the importance of continued research to better understand the endocannabinoid system and its potential applications in medicine.The article discusses the molecular logic of endocannabinoid signaling, focusing on the role of endocannabinoids in the brain. Endocannabinoids are lipid messengers that interact with cannabinoid receptors, such as CB1 and CB2, and are involved in various short-range signaling processes. They modulate synaptic efficacy and have therapeutic potential. The article traces the history of Cannabis, its discovery, and the identification of its active compound, THC. It describes the molecular cloning of CB1 and CB2 receptors and the subsequent discovery of endogenous ligands like anandamide and 2-AG. The article explains the biosynthesis, release, and deactivation of endocannabinoids, including their roles in synaptic plasticity, neurotransmission, and behavior. It also discusses the involvement of endocannabinoids in various brain functions, such as memory, emotion, motor activity, and pain regulation. The article highlights the therapeutic potential of endocannabinoids, particularly in the treatment of conditions like obesity and addiction. It also addresses the challenges in understanding the full mechanisms of endocannabinoid signaling, including the need for further research on their molecular pathways and interactions with other neurotransmitters. The article concludes with a discussion of the importance of continued research to better understand the endocannabinoid system and its potential applications in medicine.