Luff et al. demonstrate that single neurons can act as signal mixers, creating new oscillatory frequencies from exogenous or endogenous subthreshold membrane potential oscillations. This frequency mixing originates in voltage-gated ion channels and is evident in human brain activity, particularly in the human electroencephalogram (EEG). The study shows that the human EEG displays local and inter-regional frequency mixing interactions, with the mixing of posterior alpha and beta oscillations correlating with visual attention. The findings suggest that individual neurons can sculpt the spectrum of neural circuit oscillations and utilize them for computational operations, potentially modulating cognitive functions such as visual attention.Luff et al. demonstrate that single neurons can act as signal mixers, creating new oscillatory frequencies from exogenous or endogenous subthreshold membrane potential oscillations. This frequency mixing originates in voltage-gated ion channels and is evident in human brain activity, particularly in the human electroencephalogram (EEG). The study shows that the human EEG displays local and inter-regional frequency mixing interactions, with the mixing of posterior alpha and beta oscillations correlating with visual attention. The findings suggest that individual neurons can sculpt the spectrum of neural circuit oscillations and utilize them for computational operations, potentially modulating cognitive functions such as visual attention.