Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center grants permission for free access to research in PubMed Central and other repositories. The article reviews the pathogenesis and treatment of the "cytokine storm" in COVID-19, focusing on mechanisms and therapeutic strategies. SARS-CoV-2, a highly pathogenic coronavirus, causes severe respiratory disease. Cytokine storm, characterized by excessive cytokine release, is linked to severe disease progression and high mortality. The article discusses the role of cytokine storms in ARDS and multi-organ failure, and explores treatment options including immunomodulators, corticosteroids, IVIG, IL-1 and IL-6 antagonists, TNF blockers, IFN-λ, and other therapies. It also highlights the importance of timely intervention to prevent cytokine storm and improve patient outcomes. The study emphasizes the need for further research to develop effective treatments for cytokine storm in COVID-19.Elsevier established a free COVID-19 resource center in January 2020, offering English and Mandarin information on the virus. The center grants permission for free access to research in PubMed Central and other repositories. The article reviews the pathogenesis and treatment of the "cytokine storm" in COVID-19, focusing on mechanisms and therapeutic strategies. SARS-CoV-2, a highly pathogenic coronavirus, causes severe respiratory disease. Cytokine storm, characterized by excessive cytokine release, is linked to severe disease progression and high mortality. The article discusses the role of cytokine storms in ARDS and multi-organ failure, and explores treatment options including immunomodulators, corticosteroids, IVIG, IL-1 and IL-6 antagonists, TNF blockers, IFN-λ, and other therapies. It also highlights the importance of timely intervention to prevent cytokine storm and improve patient outcomes. The study emphasizes the need for further research to develop effective treatments for cytokine storm in COVID-19.