The article reviews the pathogenesis and treatment strategies of the cytokine storm induced by the novel coronavirus (COVID-19). The cytokine storm is a maladaptive immune response characterized by excessive production of proinflammatory cytokines and chemokines, leading to acute respiratory distress syndrome (ARDS) and multiple-organ failure. The review highlights the complex mechanisms involved, including the dysregulation of proinflammatory cytokine production at both local and systemic levels. It discusses various treatment options, such as interferon-λ, corticosteroids, intravenous immunoglobulin (IVIG), IL-1 family antagonists, IL-6 antagonists, TNF blockers, IFN-αβ inhibitors, chloroquine, ulinastatin, oxidized phospholipids (OxPL) inhibitors, sphingosine-1-phosphate receptor 1 agonists, and stem cell therapy. The article emphasizes the importance of early intervention to control the cytokine storm and reduce the severity of COVID-19.The article reviews the pathogenesis and treatment strategies of the cytokine storm induced by the novel coronavirus (COVID-19). The cytokine storm is a maladaptive immune response characterized by excessive production of proinflammatory cytokines and chemokines, leading to acute respiratory distress syndrome (ARDS) and multiple-organ failure. The review highlights the complex mechanisms involved, including the dysregulation of proinflammatory cytokine production at both local and systemic levels. It discusses various treatment options, such as interferon-λ, corticosteroids, intravenous immunoglobulin (IVIG), IL-1 family antagonists, IL-6 antagonists, TNF blockers, IFN-αβ inhibitors, chloroquine, ulinastatin, oxidized phospholipids (OxPL) inhibitors, sphingosine-1-phosphate receptor 1 agonists, and stem cell therapy. The article emphasizes the importance of early intervention to control the cytokine storm and reduce the severity of COVID-19.