Squalene (SQ) is a triterpene compound with significant physiological functions and potential applications in animal husbandry. This review highlights the structure, properties, and biological activities of SQ, emphasizing its anti-inflammatory, antioxidant, and cardiovascular health benefits. SQ's ability to reduce inflammatory factors, alleviate oxidative stress, and protect against exogenous toxins makes it a promising candidate for various applications in livestock and poultry production. The review also explores SQ's potential as a stress relief agent, gut health promoter, skin protector, detoxifier, and quality-improving agent in livestock products. Additionally, SQ's use as a vaccine adjuvant, antibacterial agent, and sustained-release carrier is discussed, highlighting its broader application prospects in animal husbandry. The authors conclude that SQ has significant potential for contributing to green and sustainable farming practices.Squalene (SQ) is a triterpene compound with significant physiological functions and potential applications in animal husbandry. This review highlights the structure, properties, and biological activities of SQ, emphasizing its anti-inflammatory, antioxidant, and cardiovascular health benefits. SQ's ability to reduce inflammatory factors, alleviate oxidative stress, and protect against exogenous toxins makes it a promising candidate for various applications in livestock and poultry production. The review also explores SQ's potential as a stress relief agent, gut health promoter, skin protector, detoxifier, and quality-improving agent in livestock products. Additionally, SQ's use as a vaccine adjuvant, antibacterial agent, and sustained-release carrier is discussed, highlighting its broader application prospects in animal husbandry. The authors conclude that SQ has significant potential for contributing to green and sustainable farming practices.