The study estimates that up to half of Alzheimer's disease (AD) cases globally and in the US could be attributed to seven potentially modifiable risk factors: diabetes, mid-life hypertension, mid-life obesity, smoking, depression, low educational attainment, and physical inactivity. These factors collectively contribute to 17.2 million AD cases worldwide and 2.9 million in the US. A 10–25% reduction in all seven risk factors could potentially prevent 1.1–3.0 million cases globally and 184,000–492,000 cases in the US. Diabetes contributes to approximately 2% of global AD cases, with 3% in the US. A 10% reduction in diabetes prevalence could prevent over 80,000 cases globally and nearly 17,000 in the US, while a 25% reduction could prevent over 200,000 cases globally and 40,000 in the US. Mid-life hypertension contributes to 5% of global AD cases, with 8% in the US. A 10% reduction could prevent over 160,000 cases globally and nearly 40,000 in the US, while a 25% reduction could prevent over 400,000 cases globally and nearly 100,000 in the US. Mid-life obesity contributes to 2% of global AD cases, with 7.3% in the US. A 10% reduction could prevent over 66,000 cases globally and 36,000 in the US, while a 25% reduction could prevent over 166,000 cases globally and 91,000 in the US. Depression contributes to over 10% of global AD cases, with 15% in the US. A 10% reduction could prevent over 325,000 cases globally and 67,000 in the US, while a 25% reduction could prevent over 826,000 cases globally and 172,000 in the US. Physical inactivity contributes to 13% of global AD cases, with 21% in the US. A 10% reduction could prevent over 380,000 cases globally and nearly 90,000 in the US, while a 25% reduction could prevent nearly 1 million cases globally and 230,000 in the US. Smoking contributes to nearly 14% of global AD cases, with 11% in the US. A 10% reduction could prevent over 400,000The study estimates that up to half of Alzheimer's disease (AD) cases globally and in the US could be attributed to seven potentially modifiable risk factors: diabetes, mid-life hypertension, mid-life obesity, smoking, depression, low educational attainment, and physical inactivity. These factors collectively contribute to 17.2 million AD cases worldwide and 2.9 million in the US. A 10–25% reduction in all seven risk factors could potentially prevent 1.1–3.0 million cases globally and 184,000–492,000 cases in the US. Diabetes contributes to approximately 2% of global AD cases, with 3% in the US. A 10% reduction in diabetes prevalence could prevent over 80,000 cases globally and nearly 17,000 in the US, while a 25% reduction could prevent over 200,000 cases globally and 40,000 in the US. Mid-life hypertension contributes to 5% of global AD cases, with 8% in the US. A 10% reduction could prevent over 160,000 cases globally and nearly 40,000 in the US, while a 25% reduction could prevent over 400,000 cases globally and nearly 100,000 in the US. Mid-life obesity contributes to 2% of global AD cases, with 7.3% in the US. A 10% reduction could prevent over 66,000 cases globally and 36,000 in the US, while a 25% reduction could prevent over 166,000 cases globally and 91,000 in the US. Depression contributes to over 10% of global AD cases, with 15% in the US. A 10% reduction could prevent over 325,000 cases globally and 67,000 in the US, while a 25% reduction could prevent over 826,000 cases globally and 172,000 in the US. Physical inactivity contributes to 13% of global AD cases, with 21% in the US. A 10% reduction could prevent over 380,000 cases globally and nearly 90,000 in the US, while a 25% reduction could prevent nearly 1 million cases globally and 230,000 in the US. Smoking contributes to nearly 14% of global AD cases, with 11% in the US. A 10% reduction could prevent over 400,000