The article discusses the origin of SARS-CoV-2, the virus causing COVID-19, and reviews the genomic features that suggest it is not a laboratory construct. Key features include the optimized binding to human ACE2 receptors and the presence of a polybasic furin cleavage site with O-linked glycans. The authors propose two scenarios for the virus's origin: natural selection in an animal host before zoonotic transfer or natural selection in humans following such transfer. They argue that the virus's unique features are more likely the result of natural evolution, supported by the discovery of similar coronaviruses in pangolins and bats. The article emphasizes the importance of further research, including serological studies and the identification of potential intermediate hosts, to fully understand the virus's origins and prevent future zoonotic events.The article discusses the origin of SARS-CoV-2, the virus causing COVID-19, and reviews the genomic features that suggest it is not a laboratory construct. Key features include the optimized binding to human ACE2 receptors and the presence of a polybasic furin cleavage site with O-linked glycans. The authors propose two scenarios for the virus's origin: natural selection in an animal host before zoonotic transfer or natural selection in humans following such transfer. They argue that the virus's unique features are more likely the result of natural evolution, supported by the discovery of similar coronaviruses in pangolins and bats. The article emphasizes the importance of further research, including serological studies and the identification of potential intermediate hosts, to fully understand the virus's origins and prevent future zoonotic events.