The psychological impact of the COVID-19 pandemic on the general population has been significant, with widespread stress, anxiety, depression, frustration, and uncertainty. This review aims to summarize the current literature on the mental health effects of the pandemic and the associated psychological reactions. The pandemic has led to social isolation, quarantine, and lockdown measures, which have caused emotional distress and psychological issues in the general population. The psychological impact of quarantine has been documented, along with the most relevant psychological reactions in the general population related to the pandemic. The role of risk and protective factors against the potential development of psychiatric disorders in vulnerable individuals has also been addressed. The pandemic has caused a range of psychological reactions, including fear, anxiety, frustration, and loneliness. These reactions are often linked to the social isolation and restrictions imposed during the pandemic. Additionally, the lack of adequate information and supplies has contributed to feelings of uncertainty and anxiety. Protective factors such as resilience and social support have been identified as important in mitigating the psychological impact of the pandemic. The review highlights the importance of community-based strategies to support resilience and vulnerable individuals during the pandemic. Preventive strategies, including effective communication and adequate psychological services, are essential to reduce the psychological and psychosocial impact of the pandemic. The review also emphasizes the need for targeted mental health support for at-risk populations and the implementation of telemedicine to improve access to mental health services. Overall, the psychological impact of the pandemic on the general population is a critical public health issue that requires immediate attention and action.The psychological impact of the COVID-19 pandemic on the general population has been significant, with widespread stress, anxiety, depression, frustration, and uncertainty. This review aims to summarize the current literature on the mental health effects of the pandemic and the associated psychological reactions. The pandemic has led to social isolation, quarantine, and lockdown measures, which have caused emotional distress and psychological issues in the general population. The psychological impact of quarantine has been documented, along with the most relevant psychological reactions in the general population related to the pandemic. The role of risk and protective factors against the potential development of psychiatric disorders in vulnerable individuals has also been addressed. The pandemic has caused a range of psychological reactions, including fear, anxiety, frustration, and loneliness. These reactions are often linked to the social isolation and restrictions imposed during the pandemic. Additionally, the lack of adequate information and supplies has contributed to feelings of uncertainty and anxiety. Protective factors such as resilience and social support have been identified as important in mitigating the psychological impact of the pandemic. The review highlights the importance of community-based strategies to support resilience and vulnerable individuals during the pandemic. Preventive strategies, including effective communication and adequate psychological services, are essential to reduce the psychological and psychosocial impact of the pandemic. The review also emphasizes the need for targeted mental health support for at-risk populations and the implementation of telemedicine to improve access to mental health services. Overall, the psychological impact of the pandemic on the general population is a critical public health issue that requires immediate attention and action.