This review explores the regulatory relationship between the transcription factor STAT3 and noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs). STAT3 is a key regulator in various carcinogenic signaling pathways and plays a critical role in tumor formation, metastasis, and drug resistance. Recent studies have shown that STAT3 can regulate the expression of ncRNAs, which in turn influence STAT3 activity, forming a mutual regulatory loop. This review summarizes the mechanisms by which STAT3 regulates lncRNAs, miRNAs, and circRNAs, and discusses the regulatory effects of ncRNAs on STAT3. It also highlights the potential of targeting STAT3 or ncRNAs for cancer therapy. The review emphasizes the importance of understanding the interaction between STAT3 and ncRNAs to develop new therapeutic strategies for cancer. The study also discusses the role of STAT3 in regulating the expression of lncRNAs and miRNAs, which can affect tumor cell proliferation, migration, and invasion. Additionally, it explores the impact of STAT3 on the expression of circRNAs and their role in cancer progression. The review concludes that further research is needed to fully understand the regulatory mechanisms between STAT3 and ncRNAs, and to develop effective therapeutic approaches for cancer treatment.This review explores the regulatory relationship between the transcription factor STAT3 and noncoding RNAs (ncRNAs), including long noncoding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs). STAT3 is a key regulator in various carcinogenic signaling pathways and plays a critical role in tumor formation, metastasis, and drug resistance. Recent studies have shown that STAT3 can regulate the expression of ncRNAs, which in turn influence STAT3 activity, forming a mutual regulatory loop. This review summarizes the mechanisms by which STAT3 regulates lncRNAs, miRNAs, and circRNAs, and discusses the regulatory effects of ncRNAs on STAT3. It also highlights the potential of targeting STAT3 or ncRNAs for cancer therapy. The review emphasizes the importance of understanding the interaction between STAT3 and ncRNAs to develop new therapeutic strategies for cancer. The study also discusses the role of STAT3 in regulating the expression of lncRNAs and miRNAs, which can affect tumor cell proliferation, migration, and invasion. Additionally, it explores the impact of STAT3 on the expression of circRNAs and their role in cancer progression. The review concludes that further research is needed to fully understand the regulatory mechanisms between STAT3 and ncRNAs, and to develop effective therapeutic approaches for cancer treatment.