The rhizosphere microbiome plays a crucial role in plant health by influencing disease suppression and defense mechanisms. Plants can actively shape their root microbiome through the secretion of compounds that stimulate or inhibit microbial communities. This interaction is vital for plant health, as the rhizosphere microbiome can suppress pathogens and enhance plant resistance. The diversity of microbes in the rhizosphere is immense, with tens of thousands of species, and the collective genome of these microbes is larger than that of the plant itself. Disease-suppressive soils can suppress pathogens through the activity of specific microbial communities, which can be influenced by factors such as soil type and plant genotype. The rhizosphere microbiome can also be affected by plant defense responses, leading to changes in microbial composition and activity. Beneficial microbes, such as certain bacteria and fungi, can induce systemic resistance in plants, enhancing their ability to defend against pathogens. The plant's ability to control its microbiome is influenced by its genotype and the surrounding soil. Different plant species and genotypes can support distinct microbial communities, which can affect plant health and disease resistance. The interaction between plants and their microbiome is complex, with various microbial groups contributing to disease suppression and plant defense. Recent advances in understanding plant-microbe interactions have revealed that plants can recruit beneficial microbes to suppress pathogens and enhance their defenses. The rhizosphere microbiome is a dynamic system that responds to plant signals and environmental factors, playing a key role in plant health and productivity. Future research using next-generation sequencing techniques will provide new insights into the complex interactions between plants and their microbiome, offering opportunities to improve crop quality and productivity.The rhizosphere microbiome plays a crucial role in plant health by influencing disease suppression and defense mechanisms. Plants can actively shape their root microbiome through the secretion of compounds that stimulate or inhibit microbial communities. This interaction is vital for plant health, as the rhizosphere microbiome can suppress pathogens and enhance plant resistance. The diversity of microbes in the rhizosphere is immense, with tens of thousands of species, and the collective genome of these microbes is larger than that of the plant itself. Disease-suppressive soils can suppress pathogens through the activity of specific microbial communities, which can be influenced by factors such as soil type and plant genotype. The rhizosphere microbiome can also be affected by plant defense responses, leading to changes in microbial composition and activity. Beneficial microbes, such as certain bacteria and fungi, can induce systemic resistance in plants, enhancing their ability to defend against pathogens. The plant's ability to control its microbiome is influenced by its genotype and the surrounding soil. Different plant species and genotypes can support distinct microbial communities, which can affect plant health and disease resistance. The interaction between plants and their microbiome is complex, with various microbial groups contributing to disease suppression and plant defense. Recent advances in understanding plant-microbe interactions have revealed that plants can recruit beneficial microbes to suppress pathogens and enhance their defenses. The rhizosphere microbiome is a dynamic system that responds to plant signals and environmental factors, playing a key role in plant health and productivity. Future research using next-generation sequencing techniques will provide new insights into the complex interactions between plants and their microbiome, offering opportunities to improve crop quality and productivity.