The article explores the role of gut microbiota in intestinal diseases, particularly focusing on the oxidative stress perspective. It highlights the bidirectional relationship between gut microbiota and oxidative stress, where gut microbiota can influence oxidative stress through metabolite synthesis, antioxidant enzyme regulation, and gut homeostasis maintenance, while oxidative stress can disrupt gut microbiota balance, leading to dysbiosis. The article discusses how dysbiosis-induced oxidative stress can lead to chronic inflammation, immune responses, and DNA damage, contributing to the development of intestinal disorders such as colorectal cancer (CRC), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). It also reviews therapeutic approaches, including probiotics, prebiotics, fecal microbiota transplantation (FMT), and antibiotics, which can modulate gut microbiota to restore redox equilibrium and mitigate immunological dysregulation. The article emphasizes the importance of maintaining a balanced and diverse gut microbiota through healthy lifestyle factors and dietary interventions to prevent and treat intestinal diseases.The article explores the role of gut microbiota in intestinal diseases, particularly focusing on the oxidative stress perspective. It highlights the bidirectional relationship between gut microbiota and oxidative stress, where gut microbiota can influence oxidative stress through metabolite synthesis, antioxidant enzyme regulation, and gut homeostasis maintenance, while oxidative stress can disrupt gut microbiota balance, leading to dysbiosis. The article discusses how dysbiosis-induced oxidative stress can lead to chronic inflammation, immune responses, and DNA damage, contributing to the development of intestinal disorders such as colorectal cancer (CRC), irritable bowel syndrome (IBS), and inflammatory bowel disease (IBD). It also reviews therapeutic approaches, including probiotics, prebiotics, fecal microbiota transplantation (FMT), and antibiotics, which can modulate gut microbiota to restore redox equilibrium and mitigate immunological dysregulation. The article emphasizes the importance of maintaining a balanced and diverse gut microbiota through healthy lifestyle factors and dietary interventions to prevent and treat intestinal diseases.