The article "The role of tumor-associated macrophages in tumor immune evasion" by Ruizhe Huang, Ting Kang, and Siyu Chen reviews the role of tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) and their mechanisms of immune evasion. TAMs, similar to M2 macrophages, are key regulators in the TME, influencing tumor growth, metastasis, and immune response. They release cytokines that inhibit effector immune cells, attract immunosuppressive cells, and target effector T cells, leading to immune exhaustion. TAMs also promote tumor proliferation, angiogenesis, invasion, and metastasis. The article discusses potential therapeutic strategies targeting TAMs, including epigenetic modifications, metabolic reprogramming, and cellular engineering. Despite some strategies being distant from clinical application, the authors believe that future therapies targeting TAMs will offer significant benefits to cancer patients. The review highlights the importance of understanding the complex interactions between TAMs and other TME elements to develop effective cancer immunotherapies.The article "The role of tumor-associated macrophages in tumor immune evasion" by Ruizhe Huang, Ting Kang, and Siyu Chen reviews the role of tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) and their mechanisms of immune evasion. TAMs, similar to M2 macrophages, are key regulators in the TME, influencing tumor growth, metastasis, and immune response. They release cytokines that inhibit effector immune cells, attract immunosuppressive cells, and target effector T cells, leading to immune exhaustion. TAMs also promote tumor proliferation, angiogenesis, invasion, and metastasis. The article discusses potential therapeutic strategies targeting TAMs, including epigenetic modifications, metabolic reprogramming, and cellular engineering. Despite some strategies being distant from clinical application, the authors believe that future therapies targeting TAMs will offer significant benefits to cancer patients. The review highlights the importance of understanding the complex interactions between TAMs and other TME elements to develop effective cancer immunotherapies.