The article discusses the complex causes of antimicrobial resistance (AMR) in developing countries, emphasizing the role of healthcare practices, patient behavior, and supply chain issues. Key factors include inappropriate prescription practices, inadequate patient education, limited diagnostic facilities, unauthorized sales of antimicrobials, and the misuse of antimicrobials in animal production. The authors highlight the need for context-specific interventions that address root causes unique to these regions. They also explore alternative therapies such as bacteriophage therapy, quorum sensing inhibitors, and probiotics, and emphasize the importance of hygiene, sanitation, and vaccination in controlling AMR. The article concludes by calling for a multi-disciplinary approach involving various stakeholders, including government regulatory agencies, to effectively combat AMR.The article discusses the complex causes of antimicrobial resistance (AMR) in developing countries, emphasizing the role of healthcare practices, patient behavior, and supply chain issues. Key factors include inappropriate prescription practices, inadequate patient education, limited diagnostic facilities, unauthorized sales of antimicrobials, and the misuse of antimicrobials in animal production. The authors highlight the need for context-specific interventions that address root causes unique to these regions. They also explore alternative therapies such as bacteriophage therapy, quorum sensing inhibitors, and probiotics, and emphasize the importance of hygiene, sanitation, and vaccination in controlling AMR. The article concludes by calling for a multi-disciplinary approach involving various stakeholders, including government regulatory agencies, to effectively combat AMR.