Antimicrobial resistance (AMR) is a growing threat in developing countries, driven by factors such as inappropriate prescription practices, inadequate patient education, limited diagnostic facilities, unauthorized sale of antimicrobials, and non-human use in animal production. These factors vary between developing and developed countries, necessitating targeted interventions. AMR is exacerbated by the availability of antimicrobials over the counter, poor drug quality, counterfeit drugs, and misuse by patients. Health professionals often prescribe inappropriate antibiotics due to high patient-doctor ratios and lack of evidence-based practices. Patients may also misuse antimicrobials due to poverty, self-medication, or non-compliance. Non-human use of antimicrobials in agriculture and animal production contributes to resistance development. Antimicrobial resistance control strategies include improving hygiene, vaccination, alternative therapies like bacteriophage therapy and probiotics, and enhancing surveillance and regulation. Governments and stakeholders must collaborate to address AMR through education, policy, and resource allocation. Effective control requires a multi-disciplinary approach to reduce the spread of resistant organisms and minimize the impact on human and animal health.Antimicrobial resistance (AMR) is a growing threat in developing countries, driven by factors such as inappropriate prescription practices, inadequate patient education, limited diagnostic facilities, unauthorized sale of antimicrobials, and non-human use in animal production. These factors vary between developing and developed countries, necessitating targeted interventions. AMR is exacerbated by the availability of antimicrobials over the counter, poor drug quality, counterfeit drugs, and misuse by patients. Health professionals often prescribe inappropriate antibiotics due to high patient-doctor ratios and lack of evidence-based practices. Patients may also misuse antimicrobials due to poverty, self-medication, or non-compliance. Non-human use of antimicrobials in agriculture and animal production contributes to resistance development. Antimicrobial resistance control strategies include improving hygiene, vaccination, alternative therapies like bacteriophage therapy and probiotics, and enhancing surveillance and regulation. Governments and stakeholders must collaborate to address AMR through education, policy, and resource allocation. Effective control requires a multi-disciplinary approach to reduce the spread of resistant organisms and minimize the impact on human and animal health.