The study investigates the role of mTOR signaling in cancer initiation and metastasis. Using ribosome profiling, the authors identify a specific set of genes involved in cell proliferation, metabolism, and invasion that are regulated by oncogenic mTOR signaling. They also characterize a class of translationally controlled pro-invasion mRNAs that directly promote prostate cancer invasion and metastasis. Additionally, they develop a clinically relevant mTOR inhibitor, INK128, which reprograms the gene expression signature and shows therapeutic benefit for prostate cancer metastasis. The findings highlight the importance of translational regulation in cancer development and provide a potential therapeutic target for prostate cancer.The study investigates the role of mTOR signaling in cancer initiation and metastasis. Using ribosome profiling, the authors identify a specific set of genes involved in cell proliferation, metabolism, and invasion that are regulated by oncogenic mTOR signaling. They also characterize a class of translationally controlled pro-invasion mRNAs that directly promote prostate cancer invasion and metastasis. Additionally, they develop a clinically relevant mTOR inhibitor, INK128, which reprograms the gene expression signature and shows therapeutic benefit for prostate cancer metastasis. The findings highlight the importance of translational regulation in cancer development and provide a potential therapeutic target for prostate cancer.