The updated Consolidated Framework for Implementation Research (CFIR) is a significant revision based on feedback from experienced users. The CFIR is a widely used determinant framework to assess contextual factors influencing implementation efforts. The update addresses key critiques and includes revisions to existing domains and constructs, as well as additions and removals to better center innovation recipients and add determinants related to equity in implementation. The framework now contains 48 constructs and 19 subconstructs across five domains: Innovation, Outer Setting, Inner Setting, Individuals, and Implementation Process. The updates aim to improve applicability, clarity, and relevance, aligning the CFIR with other published frameworks and addressing gaps in the original version. The authors encourage continued feedback and evolution of the framework to advance implementation science.The updated Consolidated Framework for Implementation Research (CFIR) is a significant revision based on feedback from experienced users. The CFIR is a widely used determinant framework to assess contextual factors influencing implementation efforts. The update addresses key critiques and includes revisions to existing domains and constructs, as well as additions and removals to better center innovation recipients and add determinants related to equity in implementation. The framework now contains 48 constructs and 19 subconstructs across five domains: Innovation, Outer Setting, Inner Setting, Individuals, and Implementation Process. The updates aim to improve applicability, clarity, and relevance, aligning the CFIR with other published frameworks and addressing gaps in the original version. The authors encourage continued feedback and evolution of the framework to advance implementation science.