The occupational medical officer should be notified of employment. Few diabetics register on the Disabled Persons Register, but those with disabling complications may benefit from registration and seeking advice from their local disablement resettlement officer. The positive attitude towards diabetes management allows most diabetics to be employed, but satisfactory care requires efficient medical support and cooperation between the diabetic clinic, family physician, and occupational health service. Systemic lupus erythematosus (SLE) has various clinical and immunological abnormalities, and some patients may have recurrent venous thrombosis, central nervous system disease, and recurrent abortions, which may share common pathogenic mechanisms. A circulating anticardiolipin antibody is associated with these features and may interfere with clotting pathways. Studies have shown that the lupus anticoagulant is present in some SLE patients and is linked to thrombosis, recurrent abortions, and other conditions. Research has confirmed the association between the lupus anticoagulant and thrombosis, and its removal through immunosuppression may have therapeutic value. The presence of the lupus anticoagulant is also associated with pulmonary hypertension and other conditions. Studies suggest that antibodies such as anticardiolipin and antisphingomyelin may have pathogenic importance and may be linked to thrombosis and demyelination. These antibodies may be epiphenomena, but their association with thrombosis and neurological disease appears strong. Research into these antibodies has implications for other diseases involving thrombosis or demyelination.The occupational medical officer should be notified of employment. Few diabetics register on the Disabled Persons Register, but those with disabling complications may benefit from registration and seeking advice from their local disablement resettlement officer. The positive attitude towards diabetes management allows most diabetics to be employed, but satisfactory care requires efficient medical support and cooperation between the diabetic clinic, family physician, and occupational health service. Systemic lupus erythematosus (SLE) has various clinical and immunological abnormalities, and some patients may have recurrent venous thrombosis, central nervous system disease, and recurrent abortions, which may share common pathogenic mechanisms. A circulating anticardiolipin antibody is associated with these features and may interfere with clotting pathways. Studies have shown that the lupus anticoagulant is present in some SLE patients and is linked to thrombosis, recurrent abortions, and other conditions. Research has confirmed the association between the lupus anticoagulant and thrombosis, and its removal through immunosuppression may have therapeutic value. The presence of the lupus anticoagulant is also associated with pulmonary hypertension and other conditions. Studies suggest that antibodies such as anticardiolipin and antisphingomyelin may have pathogenic importance and may be linked to thrombosis and demyelination. These antibodies may be epiphenomena, but their association with thrombosis and neurological disease appears strong. Research into these antibodies has implications for other diseases involving thrombosis or demyelination.