This study investigates the photocatalytic degradation and mineralization of sulfamethoxazole (SMX) using TiO₂/zeolite composites under UV irradiation. The composites, prepared by mechanical mixing and liquid impregnation methods, were evaluated for their performance in degrading SMX in water. The TZSM1450 composite, prepared by mechanical mixing of TiO₂ with ZSM-5, exhibited the highest degradation efficiency, achieving complete SMX degradation within 10 minutes under UV light. The degradation rate constant for TZSM1450 was 0.501 min⁻¹, which was 2.08 times higher than that of pure TiO₂. The mineralization ability of the composites was assessed through total organic carbon (TOC) removal, with TZSM1450 achieving 67% mineralization of SMX after 120 minutes of photocatalytic reaction. The presence of Cl⁻ and CO₃²⁻ anions inhibited SMX degradation, while NO₃⁻ had minimal effect. The electrical energy per order for the UV/TZSM1450 system was 68.53 kWh m⁻³ order⁻¹ for SMX degradation and 4156 kWh m⁻³ order⁻¹ for mineralization. The results indicate that the TZSM1450 composite shows promising potential as a photocatalyst for both the degradation and mineralization of SMX. The study highlights the effectiveness of TiO₂/zeolite composites in the removal of SMX from water under UV irradiation.This study investigates the photocatalytic degradation and mineralization of sulfamethoxazole (SMX) using TiO₂/zeolite composites under UV irradiation. The composites, prepared by mechanical mixing and liquid impregnation methods, were evaluated for their performance in degrading SMX in water. The TZSM1450 composite, prepared by mechanical mixing of TiO₂ with ZSM-5, exhibited the highest degradation efficiency, achieving complete SMX degradation within 10 minutes under UV light. The degradation rate constant for TZSM1450 was 0.501 min⁻¹, which was 2.08 times higher than that of pure TiO₂. The mineralization ability of the composites was assessed through total organic carbon (TOC) removal, with TZSM1450 achieving 67% mineralization of SMX after 120 minutes of photocatalytic reaction. The presence of Cl⁻ and CO₃²⁻ anions inhibited SMX degradation, while NO₃⁻ had minimal effect. The electrical energy per order for the UV/TZSM1450 system was 68.53 kWh m⁻³ order⁻¹ for SMX degradation and 4156 kWh m⁻³ order⁻¹ for mineralization. The results indicate that the TZSM1450 composite shows promising potential as a photocatalyst for both the degradation and mineralization of SMX. The study highlights the effectiveness of TiO₂/zeolite composites in the removal of SMX from water under UV irradiation.