Indigenous science is gaining recognition as a vital resource for addressing environmental and societal challenges. Indigenous knowledge systems offer alternative ways of understanding and managing the environment, and their integration with Western science can lead to more sustainable solutions. The US National Science Foundation has established the Center for Braiding Indigenous Knowledges and Science (CBIKS) to promote collaboration between Indigenous and Western knowledge systems. This initiative aims to develop ethical and effective models of integration, focusing on issues like climate change, food security, and cultural preservation. CBIKS emphasizes mutual respect and reciprocal relationships between Indigenous and Western knowledge systems. Indigenous-led research is increasingly being recognized globally, with initiatives in Australia, Canada, and New Zealand also contributing to this movement. However, it is crucial that institutions support Indigenous knowledge without exploiting it. This includes respecting Indigenous sovereignty, supporting local governance, and returning expropriated land and cultural artifacts. Institutions must also address institutional barriers that prevent full participation and visibility of Indigenous worldviews. Indigenous scientists have long had to adapt to Western scientific practices, but it is now Western scientists' turn to learn from and respect Indigenous science. Supporting Indigenous-led research requires creating a climate that values pluralism while protecting the sovereignty of diverse knowledge systems. This approach can lead to solutions that benefit everyone. Robin Wall Kimmerer and Kyle A. Artelle are leading scholars in this field, advocating for the integration of Indigenous and Western knowledge systems to create a more sustainable future.Indigenous science is gaining recognition as a vital resource for addressing environmental and societal challenges. Indigenous knowledge systems offer alternative ways of understanding and managing the environment, and their integration with Western science can lead to more sustainable solutions. The US National Science Foundation has established the Center for Braiding Indigenous Knowledges and Science (CBIKS) to promote collaboration between Indigenous and Western knowledge systems. This initiative aims to develop ethical and effective models of integration, focusing on issues like climate change, food security, and cultural preservation. CBIKS emphasizes mutual respect and reciprocal relationships between Indigenous and Western knowledge systems. Indigenous-led research is increasingly being recognized globally, with initiatives in Australia, Canada, and New Zealand also contributing to this movement. However, it is crucial that institutions support Indigenous knowledge without exploiting it. This includes respecting Indigenous sovereignty, supporting local governance, and returning expropriated land and cultural artifacts. Institutions must also address institutional barriers that prevent full participation and visibility of Indigenous worldviews. Indigenous scientists have long had to adapt to Western scientific practices, but it is now Western scientists' turn to learn from and respect Indigenous science. Supporting Indigenous-led research requires creating a climate that values pluralism while protecting the sovereignty of diverse knowledge systems. This approach can lead to solutions that benefit everyone. Robin Wall Kimmerer and Kyle A. Artelle are leading scholars in this field, advocating for the integration of Indigenous and Western knowledge systems to create a more sustainable future.