Irreversible electroporation (IRE) is a novel minimally invasive technique for tissue ablation that has potential applications in cancer therapy. Unlike reversible electroporation, which is used in electrochemotherapy (ECT) to enhance drug delivery, IRE can ablate tissue without causing thermal damage or requiring adjuvant drugs. This study demonstrates that IRE can effectively ablate substantial volumes of tissue, comparable to other ablation techniques, without thermal effects. IRE is non-selective and can cause instantaneous necrosis of the entire tissue affected by the electric field, making it less desirable in some contexts. However, in the context of minimally invasive surgery, its non-selective mode of ablation is acceptable and more comparable to cryosurgery, non-selective chemical ablation, and high temperature thermal ablation. IRE has been studied extensively with in vitro cellular systems and is considered effective for destroying bacteria and amoebae. However, its potential in minimally invasive surgery for tissue ablation has not been evaluated. This study proposes that IRE can be used as a minimally invasive surgical procedure to ablate undesirable tissue without the use of adjuvant drugs. The study also evaluates the maximal extent of tissue ablation that could be accomplished by IRE prior to the onset of thermal effects using mathematical modeling and experimental data on liver tissue. The results suggest that IRE may become an important and innovative tool in the armamentarium of surgeons treating cancer.Irreversible electroporation (IRE) is a novel minimally invasive technique for tissue ablation that has potential applications in cancer therapy. Unlike reversible electroporation, which is used in electrochemotherapy (ECT) to enhance drug delivery, IRE can ablate tissue without causing thermal damage or requiring adjuvant drugs. This study demonstrates that IRE can effectively ablate substantial volumes of tissue, comparable to other ablation techniques, without thermal effects. IRE is non-selective and can cause instantaneous necrosis of the entire tissue affected by the electric field, making it less desirable in some contexts. However, in the context of minimally invasive surgery, its non-selective mode of ablation is acceptable and more comparable to cryosurgery, non-selective chemical ablation, and high temperature thermal ablation. IRE has been studied extensively with in vitro cellular systems and is considered effective for destroying bacteria and amoebae. However, its potential in minimally invasive surgery for tissue ablation has not been evaluated. This study proposes that IRE can be used as a minimally invasive surgical procedure to ablate undesirable tissue without the use of adjuvant drugs. The study also evaluates the maximal extent of tissue ablation that could be accomplished by IRE prior to the onset of thermal effects using mathematical modeling and experimental data on liver tissue. The results suggest that IRE may become an important and innovative tool in the armamentarium of surgeons treating cancer.