This study introduces a novel minimally invasive method for cancer treatment using irreversible electroporation (IRE), which involves the ablation of undesirable tissue through the irreversible permeabilization of cell membranes. Unlike reversible electroporation, which has been extensively studied and used in electrochemotherapy (ECT) to enhance the effectiveness of cytotoxic drugs, IRE has been largely overlooked in cancer therapy. The authors demonstrate through mathematical analysis that IRE can ablate substantial volumes of tissue without causing thermal damage or requiring adjuvant drugs. This technique is easy to apply, monitor, and control, and is not affected by local blood flow, making it a promising tool for surgeons treating cancer. The study focuses on the electroporation of liver tissue using two and four needle electrodes, aiming to evaluate the maximal extent of tissue ablation achievable before thermal effects become detrimental.This study introduces a novel minimally invasive method for cancer treatment using irreversible electroporation (IRE), which involves the ablation of undesirable tissue through the irreversible permeabilization of cell membranes. Unlike reversible electroporation, which has been extensively studied and used in electrochemotherapy (ECT) to enhance the effectiveness of cytotoxic drugs, IRE has been largely overlooked in cancer therapy. The authors demonstrate through mathematical analysis that IRE can ablate substantial volumes of tissue without causing thermal damage or requiring adjuvant drugs. This technique is easy to apply, monitor, and control, and is not affected by local blood flow, making it a promising tool for surgeons treating cancer. The study focuses on the electroporation of liver tissue using two and four needle electrodes, aiming to evaluate the maximal extent of tissue ablation achievable before thermal effects become detrimental.