A global survey of researchers published in 2021 and early 2022 reveals that preprinting is more widely adopted in the United States and Europe, with higher familiarity and commitment to preprinting compared to other regions. Physics, astronomy, mathematics, and computer science show the strongest adoption of preprinting. Researchers identified free accessibility and faster communication as the most important benefits of preprinting, while concerns include low reliability, premature media coverage, and the risk of scooping. The most effective strategies to encourage preprinting are integrating preprinting into journal submission workflows and providing recognition for posting preprints. Researchers in the life and health sciences expressed particular concerns about the credibility of preprints and the risk of being scooped. The survey also found that men are more likely to adopt preprinting than women, and researchers with less experience are more willing to post preprints. The study highlights the need for better integration of preprinting into journal workflows, improved quality assurance, and clearer guidelines for citation and copyright. The findings suggest that preprinting is an important part of open science, but challenges remain in addressing concerns about reliability and credibility. The survey results emphasize the importance of promoting preprinting while addressing the concerns of researchers.A global survey of researchers published in 2021 and early 2022 reveals that preprinting is more widely adopted in the United States and Europe, with higher familiarity and commitment to preprinting compared to other regions. Physics, astronomy, mathematics, and computer science show the strongest adoption of preprinting. Researchers identified free accessibility and faster communication as the most important benefits of preprinting, while concerns include low reliability, premature media coverage, and the risk of scooping. The most effective strategies to encourage preprinting are integrating preprinting into journal submission workflows and providing recognition for posting preprints. Researchers in the life and health sciences expressed particular concerns about the credibility of preprints and the risk of being scooped. The survey also found that men are more likely to adopt preprinting than women, and researchers with less experience are more willing to post preprints. The study highlights the need for better integration of preprinting into journal workflows, improved quality assurance, and clearer guidelines for citation and copyright. The findings suggest that preprinting is an important part of open science, but challenges remain in addressing concerns about reliability and credibility. The survey results emphasize the importance of promoting preprinting while addressing the concerns of researchers.