This review discusses the development and application of solvent selection guides for promoting green chemistry. Green solvents are defined based on environmental, health, and safety (EHS) criteria, with tools like the ETH Zurich and Rowan University approaches providing numerical rankings. These tools consider factors such as energy demand, toxicity, and environmental impact. The review highlights the importance of reducing the use of hazardous solvents, particularly in pharmaceutical and chemical industries, and the need for alternatives that are safer and more sustainable. Regulatory frameworks such as REACH have imposed restrictions on certain solvents, including toluene, chloroform, and dichloromethane (DCM), due to their environmental and health risks. Solvent selection guides have been developed to help identify safer alternatives, with tools like the Pfizer, GSK, and Sanofi guides providing recommendations based on regulatory and environmental criteria. These guides often categorize solvents as 'preferred', 'usable', or 'undesirable', with a focus on minimizing environmental impact and health risks. The review also discusses the use of bio-based solvents as alternatives to traditional petrochemical solvents, emphasizing their renewability and reduced environmental impact. However, the availability and feasibility of bio-based solvents are still limited, and more research is needed to develop sustainable alternatives. The CHEM21 project has developed a new solvent selection guide that incorporates regulatory and environmental criteria, providing a more comprehensive assessment of solvent greenness. The review concludes that while solvent selection guides are valuable tools for promoting green chemistry, there is a need for continued research and development to improve the accuracy and reliability of these tools. The integration of bio-based solvents into the chemical industry is essential for achieving sustainable practices, but challenges remain in terms of availability, cost, and regulatory acceptance. Overall, the use of green solvents is a critical step towards reducing the environmental impact of chemical processes and promoting sustainable development.This review discusses the development and application of solvent selection guides for promoting green chemistry. Green solvents are defined based on environmental, health, and safety (EHS) criteria, with tools like the ETH Zurich and Rowan University approaches providing numerical rankings. These tools consider factors such as energy demand, toxicity, and environmental impact. The review highlights the importance of reducing the use of hazardous solvents, particularly in pharmaceutical and chemical industries, and the need for alternatives that are safer and more sustainable. Regulatory frameworks such as REACH have imposed restrictions on certain solvents, including toluene, chloroform, and dichloromethane (DCM), due to their environmental and health risks. Solvent selection guides have been developed to help identify safer alternatives, with tools like the Pfizer, GSK, and Sanofi guides providing recommendations based on regulatory and environmental criteria. These guides often categorize solvents as 'preferred', 'usable', or 'undesirable', with a focus on minimizing environmental impact and health risks. The review also discusses the use of bio-based solvents as alternatives to traditional petrochemical solvents, emphasizing their renewability and reduced environmental impact. However, the availability and feasibility of bio-based solvents are still limited, and more research is needed to develop sustainable alternatives. The CHEM21 project has developed a new solvent selection guide that incorporates regulatory and environmental criteria, providing a more comprehensive assessment of solvent greenness. The review concludes that while solvent selection guides are valuable tools for promoting green chemistry, there is a need for continued research and development to improve the accuracy and reliability of these tools. The integration of bio-based solvents into the chemical industry is essential for achieving sustainable practices, but challenges remain in terms of availability, cost, and regulatory acceptance. Overall, the use of green solvents is a critical step towards reducing the environmental impact of chemical processes and promoting sustainable development.