The study examines the prescribing patterns of topical antifungals and antifungal-corticosteroid combinations among Medicare Part D beneficiaries in the United States during 2021. Using CMS data, the CDC analyzed prescription volumes, rates, and costs. In 2021, approximately 6.5 million topical antifungal prescriptions were filled, costing $231 million. Primary care physicians wrote the highest percentage of prescriptions (40.0%), followed by nurse practitioners or physician assistants (21.4%), dermatologists (17.6%), and podiatrists (14.1%). Higher-volume prescribers wrote 44.2% of all prescriptions. The study highlights the importance of understanding current prescribing practices and promoting judicious use of these medications to prevent the emergence and spread of antimicrobial-resistant superficial fungal infections.The study examines the prescribing patterns of topical antifungals and antifungal-corticosteroid combinations among Medicare Part D beneficiaries in the United States during 2021. Using CMS data, the CDC analyzed prescription volumes, rates, and costs. In 2021, approximately 6.5 million topical antifungal prescriptions were filled, costing $231 million. Primary care physicians wrote the highest percentage of prescriptions (40.0%), followed by nurse practitioners or physician assistants (21.4%), dermatologists (17.6%), and podiatrists (14.1%). Higher-volume prescribers wrote 44.2% of all prescriptions. The study highlights the importance of understanding current prescribing practices and promoting judicious use of these medications to prevent the emergence and spread of antimicrobial-resistant superficial fungal infections.