The chapter by Jean-Marie Lehn explores the evolution of matter from simple to complex forms through self-organization, focusing on supramolecular chemistry. It highlights the transition from molecular chemistry, which focuses on covalent bonds, to supramolecular chemistry, which deals with noncovalent interactions. The author discusses the development of supramolecular chemistry over the past quarter-century, emphasizing its interdisciplinary nature and its role in advancing fields such as biology and physics. The chapter outlines three phases of supramolecular chemistry: molecular recognition, self-assembly, and self-organization, each contributing to the complexity of systems. It also delves into the concept of molecular information, where the structure and dynamics of matter are controlled through noncovalent interactions. The text further explores the potential of supramolecular chemistry in creating adaptive and evolutive systems, including the design of "learning" chemical systems. Finally, it discusses the impact of supramolecular chemistry on materials science, particularly in the development of smart materials and nanomaterials, and the potential for these materials to be used in various applications, from drug delivery to molecular computing.The chapter by Jean-Marie Lehn explores the evolution of matter from simple to complex forms through self-organization, focusing on supramolecular chemistry. It highlights the transition from molecular chemistry, which focuses on covalent bonds, to supramolecular chemistry, which deals with noncovalent interactions. The author discusses the development of supramolecular chemistry over the past quarter-century, emphasizing its interdisciplinary nature and its role in advancing fields such as biology and physics. The chapter outlines three phases of supramolecular chemistry: molecular recognition, self-assembly, and self-organization, each contributing to the complexity of systems. It also delves into the concept of molecular information, where the structure and dynamics of matter are controlled through noncovalent interactions. The text further explores the potential of supramolecular chemistry in creating adaptive and evolutive systems, including the design of "learning" chemical systems. Finally, it discusses the impact of supramolecular chemistry on materials science, particularly in the development of smart materials and nanomaterials, and the potential for these materials to be used in various applications, from drug delivery to molecular computing.