The article "Tragacanth Gum-Based Hydrogels for Drug Delivery and Tissue Engineering Applications" by Gholamreza Abdi et al. reviews the properties, sources, and applications of tragacanth gum-based hydrogels. Tragacanth gum, a natural polysaccharide, is highlighted for its biocompatibility, biodegradability, and structural versatility, making it suitable for various biomedical applications. The authors discuss the chemical composition and molecular structure of tragacanth gum, emphasizing its complex heterogeneous nature. They also explore the pH-responsive behavior of tragacanth gel-based hydrogels, which can be used for controlled drug release in drug delivery systems. The article further delves into the formation and characterization of tragacanth gum-based hydrogels, including physical and chemical crosslinking methods. The potential of these hydrogels in oral, topical, and injectable drug delivery is discussed, highlighting their advantages such as mucoadhesion, high water absorption, and controlled drug release. Additionally, the article examines the use of tragacanth gum-based hydrogels in tissue engineering, particularly for scaffold fabrication and wound healing, where they provide a biocompatible and biodegradable environment for cell growth and tissue regeneration. The authors conclude by discussing recent advances and future prospects in the field, emphasizing the versatility and potential of tragacanth gum-based hydrogels in biomedical applications.The article "Tragacanth Gum-Based Hydrogels for Drug Delivery and Tissue Engineering Applications" by Gholamreza Abdi et al. reviews the properties, sources, and applications of tragacanth gum-based hydrogels. Tragacanth gum, a natural polysaccharide, is highlighted for its biocompatibility, biodegradability, and structural versatility, making it suitable for various biomedical applications. The authors discuss the chemical composition and molecular structure of tragacanth gum, emphasizing its complex heterogeneous nature. They also explore the pH-responsive behavior of tragacanth gel-based hydrogels, which can be used for controlled drug release in drug delivery systems. The article further delves into the formation and characterization of tragacanth gum-based hydrogels, including physical and chemical crosslinking methods. The potential of these hydrogels in oral, topical, and injectable drug delivery is discussed, highlighting their advantages such as mucoadhesion, high water absorption, and controlled drug release. Additionally, the article examines the use of tragacanth gum-based hydrogels in tissue engineering, particularly for scaffold fabrication and wound healing, where they provide a biocompatible and biodegradable environment for cell growth and tissue regeneration. The authors conclude by discussing recent advances and future prospects in the field, emphasizing the versatility and potential of tragacanth gum-based hydrogels in biomedical applications.