The miniaturization of metal-oxide-semiconductor field-effect transistors (MOSFETs) has been a driving force behind the development of integrated circuits over the past 60 years. However, the short channel effect limits the reduction of MOSFET gate lengths to sub-10 nm. Two-dimensional materials (2DMs) with atomic-scale thicknesses and non-dangling bonds offer a promising solution for advanced tech nodes beyond sub-3 nm. While 2DMs have shown excellent performance in laboratory settings, challenges remain in transitioning them from lab to industrial production. This review analyzes the similarities and differences between 2DMs MOSFETs and silicon MOSFETs in terms of channel, contact, and dielectric engineering. It discusses potential solutions for addressing scaling challenges and the performance metrics of 2DMs transistors. The review also highlights the importance of large-scale transfer technology and high-quality material synthesis for the commercialization of 2DMs. Despite the progress, significant technical issues need to be resolved to fully realize the potential of 2DMs in advanced tech nodes.The miniaturization of metal-oxide-semiconductor field-effect transistors (MOSFETs) has been a driving force behind the development of integrated circuits over the past 60 years. However, the short channel effect limits the reduction of MOSFET gate lengths to sub-10 nm. Two-dimensional materials (2DMs) with atomic-scale thicknesses and non-dangling bonds offer a promising solution for advanced tech nodes beyond sub-3 nm. While 2DMs have shown excellent performance in laboratory settings, challenges remain in transitioning them from lab to industrial production. This review analyzes the similarities and differences between 2DMs MOSFETs and silicon MOSFETs in terms of channel, contact, and dielectric engineering. It discusses potential solutions for addressing scaling challenges and the performance metrics of 2DMs transistors. The review also highlights the importance of large-scale transfer technology and high-quality material synthesis for the commercialization of 2DMs. Despite the progress, significant technical issues need to be resolved to fully realize the potential of 2DMs in advanced tech nodes.