This study reports a case of transplacental transmission of SARS-CoV-2 from a pregnant woman to her neonate. The mother, a 23-year-old with fever, severe cough, and neurological compromise, was diagnosed with COVID-19 during late pregnancy. A cesarean section was performed due to fetal compromise, and the neonate was born with normal vital parameters but presented with neurological manifestations similar to those observed in adult patients with COVID-19. Comprehensive virological and pathological investigations confirmed the transplacental transmission of SARS-CoV-2. The placenta showed high viral loads, diffuse peri-villous fibrin deposition, and acute and chronic intervillositis, indicating significant inflammatory response. The neonate's blood and bronchoalveolar lavage fluid also tested positive for SARS-CoV-2, confirming neonatal viremia. The study highlights the possibility of transplacental transmission during the last weeks of pregnancy and the potential for neurological complications in neonates.This study reports a case of transplacental transmission of SARS-CoV-2 from a pregnant woman to her neonate. The mother, a 23-year-old with fever, severe cough, and neurological compromise, was diagnosed with COVID-19 during late pregnancy. A cesarean section was performed due to fetal compromise, and the neonate was born with normal vital parameters but presented with neurological manifestations similar to those observed in adult patients with COVID-19. Comprehensive virological and pathological investigations confirmed the transplacental transmission of SARS-CoV-2. The placenta showed high viral loads, diffuse peri-villous fibrin deposition, and acute and chronic intervillositis, indicating significant inflammatory response. The neonate's blood and bronchoalveolar lavage fluid also tested positive for SARS-CoV-2, confirming neonatal viremia. The study highlights the possibility of transplacental transmission during the last weeks of pregnancy and the potential for neurological complications in neonates.