A 23-year-old pregnant woman with COVID-19 was admitted in March 2020 at 35+2 weeks of gestation. She presented with fever and severe cough. RT-PCR confirmed SARS-CoV-2 infection in her blood, nasopharyngeal and vaginal swabs. The infection was confirmed in the placenta and neonate. The neonate was born with neurological symptoms, similar to those seen in adults with COVID-19. Virological and pathological investigations confirmed transplacental transmission of SARS-CoV-2. The neonate showed signs of neurological compromise, including irritability, poor feeding, axial hypertonia, and opisthotonos. MRI showed bilateral gliosis of the deep white periventricular and subcortical matter. The neonate was isolated and treated with standard neonatal care. RT-PCR confirmed SARS-CoV-2 in the neonate's blood and bronchoalveolar lavage fluid. The placenta showed diffuse perivillous fibrin deposition, infarction, and acute and chronic intervillositis. Immunohistochemistry confirmed SARS-CoV-2 infection in placental tissues. The study demonstrates that SARS-CoV-2 can be transmitted from mother to fetus through the placenta. The findings suggest that transplacental transmission is possible in the last weeks of pregnancy. The neonate's neurological symptoms are consistent with SARS-CoV-2 infection. The study highlights the importance of understanding SARS-CoV-2 transmission routes to prevent neonatal infection and optimize pregnancy management. The results also emphasize the need for further research to clarify the mechanisms of transplacental transmission and its implications for fetal development.A 23-year-old pregnant woman with COVID-19 was admitted in March 2020 at 35+2 weeks of gestation. She presented with fever and severe cough. RT-PCR confirmed SARS-CoV-2 infection in her blood, nasopharyngeal and vaginal swabs. The infection was confirmed in the placenta and neonate. The neonate was born with neurological symptoms, similar to those seen in adults with COVID-19. Virological and pathological investigations confirmed transplacental transmission of SARS-CoV-2. The neonate showed signs of neurological compromise, including irritability, poor feeding, axial hypertonia, and opisthotonos. MRI showed bilateral gliosis of the deep white periventricular and subcortical matter. The neonate was isolated and treated with standard neonatal care. RT-PCR confirmed SARS-CoV-2 in the neonate's blood and bronchoalveolar lavage fluid. The placenta showed diffuse perivillous fibrin deposition, infarction, and acute and chronic intervillositis. Immunohistochemistry confirmed SARS-CoV-2 infection in placental tissues. The study demonstrates that SARS-CoV-2 can be transmitted from mother to fetus through the placenta. The findings suggest that transplacental transmission is possible in the last weeks of pregnancy. The neonate's neurological symptoms are consistent with SARS-CoV-2 infection. The study highlights the importance of understanding SARS-CoV-2 transmission routes to prevent neonatal infection and optimize pregnancy management. The results also emphasize the need for further research to clarify the mechanisms of transplacental transmission and its implications for fetal development.