The article "Treatable Traits: Toward Precision Medicine of Chronic Airway Diseases" by Alvar Agusti et al. discusses the need for a precision medicine approach to manage chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). The authors argue that these diseases are complex and heterogeneous, with different biological mechanisms (endotypes) and clinical features (phenotypes) that require individualized treatment. They propose a strategy based on identifying "treatable traits" in each patient, which can be phenotypic or based on deep understanding of causal pathways. This approach aims to improve clinical outcomes, minimize side effects, and facilitate drug development. The article highlights the limitations of current diagnostic labels and suggests that a more nuanced, label-free approach is necessary to better manage these diseases. It also outlines potential research initiatives to validate and refine the proposed strategy, including multidisciplinary workshops and rigorous clinical trials. The authors conclude that a precision medicine approach is essential to improve the management and prognosis of chronic airway diseases.The article "Treatable Traits: Toward Precision Medicine of Chronic Airway Diseases" by Alvar Agusti et al. discusses the need for a precision medicine approach to manage chronic airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). The authors argue that these diseases are complex and heterogeneous, with different biological mechanisms (endotypes) and clinical features (phenotypes) that require individualized treatment. They propose a strategy based on identifying "treatable traits" in each patient, which can be phenotypic or based on deep understanding of causal pathways. This approach aims to improve clinical outcomes, minimize side effects, and facilitate drug development. The article highlights the limitations of current diagnostic labels and suggests that a more nuanced, label-free approach is necessary to better manage these diseases. It also outlines potential research initiatives to validate and refine the proposed strategy, including multidisciplinary workshops and rigorous clinical trials. The authors conclude that a precision medicine approach is essential to improve the management and prognosis of chronic airway diseases.