This review article provides an overview of current approaches and emerging innovations in the treatment of Acute Kidney Injury (AKI). AKI is a complex and life-threatening condition with multifactorial etiologies, and its management involves treating the underlying cause, supportive care, and addressing complications. Key aspects discussed include blood pressure targets, fluid management, vasopressor therapy, indications for kidney replacement therapy (KRT), and drug considerations. The article highlights the importance of individualizing care based on patient characteristics and AKI etiology, emphasizing the need for higher blood pressure targets in AKI. It also reviews the challenges in fluid management, the role of vasopressors, and the complexities of KRT initiation and timing. Additionally, the article addresses the management of drug dosing in AKI, particularly in critically ill patients, and discusses emerging treatments and future directions in AKI management. The review aims to identify gaps and challenges in the field and offer recommendations for future research and clinical practice.This review article provides an overview of current approaches and emerging innovations in the treatment of Acute Kidney Injury (AKI). AKI is a complex and life-threatening condition with multifactorial etiologies, and its management involves treating the underlying cause, supportive care, and addressing complications. Key aspects discussed include blood pressure targets, fluid management, vasopressor therapy, indications for kidney replacement therapy (KRT), and drug considerations. The article highlights the importance of individualizing care based on patient characteristics and AKI etiology, emphasizing the need for higher blood pressure targets in AKI. It also reviews the challenges in fluid management, the role of vasopressors, and the complexities of KRT initiation and timing. Additionally, the article addresses the management of drug dosing in AKI, particularly in critically ill patients, and discusses emerging treatments and future directions in AKI management. The review aims to identify gaps and challenges in the field and offer recommendations for future research and clinical practice.