This randomized controlled trial compared the efficacy of a novel treatment for complicated grief, complicated grief treatment (CGT), with standard interpersonal psychotherapy (IPT). The study included 83 women and 12 men aged 18 to 85 years who met criteria for complicated grief. Participants were randomly assigned to receive either CGT or IPT in a 1:1 ratio. The primary outcome measure was treatment response, defined as a significant improvement in symptoms as rated by an independent evaluator or a substantial improvement in self-reported symptoms. Both treatments showed improvement in complicated grief symptoms, but CGT had a higher response rate (51%) compared to IPT (28%). The median time to response was shorter for CGT than for IPT. The study concluded that CGT is an improved treatment over IPT, with a higher response rate and faster time to response. The findings suggest that complicated grief is a specific condition requiring a targeted treatment approach. However, the study also highlighted the need for further research to confirm these findings and to explore potential moderators of treatment response.This randomized controlled trial compared the efficacy of a novel treatment for complicated grief, complicated grief treatment (CGT), with standard interpersonal psychotherapy (IPT). The study included 83 women and 12 men aged 18 to 85 years who met criteria for complicated grief. Participants were randomly assigned to receive either CGT or IPT in a 1:1 ratio. The primary outcome measure was treatment response, defined as a significant improvement in symptoms as rated by an independent evaluator or a substantial improvement in self-reported symptoms. Both treatments showed improvement in complicated grief symptoms, but CGT had a higher response rate (51%) compared to IPT (28%). The median time to response was shorter for CGT than for IPT. The study concluded that CGT is an improved treatment over IPT, with a higher response rate and faster time to response. The findings suggest that complicated grief is a specific condition requiring a targeted treatment approach. However, the study also highlighted the need for further research to confirm these findings and to explore potential moderators of treatment response.